1396787-86-2

Upstream product

• 108-94-1 cyclohexanone 
• 6149-50-4 methyl 1-hydroxycyclohexanecarboxylate 
• 107-30-2 chloromethyl methyl ether 
• 1123-28-0 1-hydroxy-cyclohexanecarboxylic acid 
• 24731-36-0 1-trimethylsilanyloxycyclohexanecarbonitrile 

Downstream Products

• 1396787-19-1 2-benzylidene-1-oxaspiro[3.5]nonan-3-one 
• 1396787-38-4 2-benzylidene-1-oxaspiro[3.5]nonan-3-one 
• 1396787-20-4 2-(4-methoxybenzylidene)-1-oxaspiro[3.5]nonan-3-one 
• 1396787-40-8 2-(4-methoxybenzylidene)-1-oxaspiro[3.5]nonan-3-one 
• 1396787-21-5 2-(4-chlorobenzylidene)-1-oxaspiro[3.5]nonan-3-one 
• 1396787-41-9 2-(4-chlorobenzylidene)-1-oxaspiro[3.5]nonan-3-one 
• 1396787-53-3 methyl 1-[(dimethoxyphosphoryl)methoxy]cyclohexanecarboxylate 

Relevant academic research and scientific papers

Method for the efficient synthesis of highly-substituted oxetan- and azetidin-, dihydrofuran- and pyrrolidin-3-ones and its application to the synthesis of (±)-pseudodeflectusin

Highly substituted four- and five-membered heterocycles were prepared starting with O,P- and N,P-acetals by using a one-pot method involving base induced cyclization and a Horner-Wadsworth-Emmons (HWE) olefination reaction. Divergent synthesis of various heterocycles was achieved by using this method and transformations of the alkenyl group in the products of these processes were exemplified. Finally, a short and efficient synthesis of (±)- pseudodeflectusin based on the new methodology was achieved.