1123-28-0

Usage

Chemical Properties

Yellow powder

InChI:InChI=1/C7H12O3/c8-6(9)7(10)4-2-1-3-5-7/h10H,1-5H2,(H,8,9)

Upstream product

• 766-66-5 2-chlorocycloheptanone 
• 931-97-5 1-hydroxy-1-cyclohexanecarbonitrile 
• 32379-48-9 1-benzoyloxy-cyclohexanecarboxylic acid amide 
• 108-94-1 cyclohexanone 
• 56-23-5 tetrachloromethane 
• 78-27-3 1-Ethynylcyclohexan-1-ol 
• 7527-61-9 7-oxa-14-aza-dispiro[5.1.5.2]pentadecan-15-one 
• 67-66-3 chloroform 
• 98-89-5 Cyclohexanecarboxylic acid 
• 1940-19-8 1-vinylcyclohexanol 
• 7647-01-0 hydrogenchloride 
• 60-29-7 diethyl ether 
• 110-86-1 pyridine 
• 52329-71-2 1-hydroxycyclohexanecarboxaldehyde 

Downstream Products

• 6149-50-4 methyl 1-hydroxycyclohexanecarboxylate 
• 1127-01-1 ethyl 1-hydroxycyclohexanecarboxylate 
• 1123-27-9 1-(1-hydroxycyclohexyl)ethan-1-one 
• 1124-96-5 2-(1-hydroxycyclohexyl)propan-2-ol 
• 18448-47-0 methyl cyclohex-1-ene-1-carboxylate 
• 27032-96-8 Pentamethylen-5,5-dioxolanon-4 
• 15753-47-6 1-(hydroxymethyl)cyclohexanol 
• 636-82-8 cyclohexene-1-carboxylic acid 
• 934-66-7 trans-4-bromo-cyclohexanecarboxylic acid 
• 5469-29-4 2-bromo-cyclohexanecarboxylic acid 
• 112681-21-7 N-phenyl-α-hydroxy-α,α-pentamethyleneacetamide 
• 108-94-1 cyclohexanone 
• 98-89-5 Cyclohexanecarboxylic acid 
• 6282-51-5 1-Acetoxycyclohexancarbonsaeure 

Relevant academic research and scientific papers

Degradation of a model naphthenic acid, cyclohexanoic acid, by vacuum UV (172 nm) and UV (254 nm)/H2O2

The mechanism of hydroxyl radical initiated degradation of a typical oil sands process water (OSPW) alicyclic carboxylic acid was studied using cyclohexanoic acid (CHA) as a model compound. By use of vacuum ultraviolet irradiation (VUV, 172 nm) and ultraviolet irradiation in the presence of hydrogen peroxide UV(254 nm)/H2O2, it was established that CHA undergoes degradation through a peroxyl radical. In both processes the decay of the peroxyl radical leads predominantly to the formation of 4-oxo-CHA, and minor amounts of hydroxy-CHA (detected only in UV/H2O 2). In UV/H2O2, additional 4-oxo-CHA may also have been formed by direct reaction of the oxyl radical with H-O 2. The oxyl radical can be formed during decay of the peroxyl-CHA radical or reaction of hydroxy-CHA with hydroxyl radical. Oxo- and hydroxy-CHA further degraded to various dihydroxy-CHAs. Scission of the cyclohexane ring was also observed, on the basis of the observation of acyclic byproducts including heptadioic acid and various short-chain carboxylic acids. Overall, the hydroxyl radical induced degradation of CHA proceeded through several steps, involving more than one hydroxyl radical reaction, thus efficiency of the UV/H 2O2 reaction will depend on the rate of generation of hydroxyl radical throughout the process. In real applications to OSPW, concentrations of H2O2 will need to be carefully optimized and the environmental fate and effects of the various degradation products of naphthenic acids considered.

New process for synthesizing 1-hydroxycyclohexanecarboxylic acid and application

The invention discloses a new process for synthesizing 1-hydroxycyclohexanecarboxylic acid and an application. During the synthesis of the 1-hydroxycyclohexanecarboxylic acid, an anhydrous system is adopted. According to the process, due to an anhydrous r

Anesthetic compounds and related methods of use

Provided herein are compounds according to formula (I): Provided herein is also a pharmaceutical composition comprising a compound according to formula (I) and a pharmaceutically acceptable carrier, and a method for providing anesthesia in a subject by administering such a pharmaceutical composition.

ANESTHETIC COMPOUNDS AND RELATED METHODS OF USE

Provided herein are compounds according to formula (I): Provided herein is also a pharmaceutical composition comprising a compound according to formula (I) and a pharmaceutically acceptable carrier, and a method for providing anesthesia in a subject by administering such a pharmaceutical composition.

Method for the efficient synthesis of highly-substituted oxetan- and azetidin-, dihydrofuran- and pyrrolidin-3-ones and its application to the synthesis of (±)-pseudodeflectusin

Highly substituted four- and five-membered heterocycles were prepared starting with O,P- and N,P-acetals by using a one-pot method involving base induced cyclization and a Horner-Wadsworth-Emmons (HWE) olefination reaction. Divergent synthesis of various heterocycles was achieved by using this method and transformations of the alkenyl group in the products of these processes were exemplified. Finally, a short and efficient synthesis of (±)- pseudodeflectusin based on the new methodology was achieved.

A practical and inexpensive 'convertible' isonitrile for use in multicomponent reactions

N-tert-Butylamides are readily converted into the corresponding carboxylic acids by simple nitrosation. The process, which occurs under mild nonaqueous conditions, leaves carboxylic esters untouched and transforms multicomponent reaction products into useful building blocks for further synthetic elaboration.

Preparation and reactions of optically active cyanohydrins derived from 4-chlorobenzaldehyde, cyclohexanone and 2-methylcyclohexanone using the (R) hydroxynitrile lyase from Prunus amygdalus

CYANURATION of 4-chlorobenzaldehyde (1), cyclohexanone (2a) and 2-methylcyclo-hexanone (2b) yielded the racemic 2-hydroxy-2-(4-chlorophenyl) ethanenitrile (R,S)-3, cyclohexanone cyanohydrin 21a and (R,S)-2- methylcyclohexanone cyanohydrin (R,S)-21b. The same reaction can be completed by using acetone cyanohydrin (4) as a transcyanating agent. The optically active cyanohydrins (R)-3 and (R)-21b could be respectively obtained by hydrocyanation of 1 and 2b using (R)-hydroxynitrile lyase (R) PaHNL [EC 4.1.2.10] from almonds (Prunus amygdalus) as a chiral catalyst. Cyanohydrins 3 and 21 in their racemic and optically active forms undergo a number of transformations which involve either the hydroxyl group or the cyanide function. Moreover, derivatization of 3 and 21b with (S)-Naproxen chloride (S)-7 gave the respective diastereoisomers 8 and 22b. The optical activities of (R)-3 and 21b as well as their derivatives were recorded. The postulated structures of the new products were supported with compatible elementary and spectroscopic (IR, 1H NMR, 13C NMR, MS and X-ray crystallography) analyses. The antitumor activity of some selected racemic new products and their respective optically active analogues were undertaken. The structure-activity relationship (SAR) was also discussed.

One-step conversion of ketones to conjugated acids using bromoform

Phase-transfer-catalyzed (PTC) reactions of ketones with bromoform and aqueous lithium hydroxide in alcoholic solvent result in the formation of ,-unsaturated carboxylic acids. The reaction was performed at room temperature for 24h. The corresponding conj

Bradykinin B1 receptor antagonists: An α-hydroxy amide with an improved metabolism profile

A series of carbo- and heterocyclic α-hydroxy amide-derived bradykinin B1 antagonists was prepared and evaluated. A 4,4-difluorocyclohexyl α-hydroxy amide was incorporated along with a 2-methyl tetrazole in lieu of an oxadiazole to afford a suitable compound with good pharmacokinetic properties, CNS penetration, and clearance by multiple metabolic pathways.

Decomposition of sodium trichloroacetate in the presence of quaternary ammonium under microwave irradiation: A convenient one-pot synthesis of α-hydroxy acids in water

A good yielding phase-transfer-catalyzed procedure for one-pot preparation of α-hydroxy acids from carbonyl compounds and sodium trichloroacetate by in situ addition and hydrolysis under microwave irradiation is described. Decomposition of sodium trichloroacetate is strongly accelerated by the presence of quaternary ammonium. The reaction can be conducted in water. Copyright Taylor & Francis Group, LLC.