130972-90-6

Basic information

• Product Name: Carbamic acid, [[4-(2-bromoethoxy)-3-methoxyphenyl]methyl]-, 1,1-dimethylethyl ester
• CAS NO: 130972-90-6
• Molecular Formula: C15H22BrNO4
• Molecular Weight: 360.248
• Mol File: 130972-90-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [[4-(2-bromoethoxy)-3-methoxyphenyl]methyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [[4-(2-bromoethoxy)-3-methoxyphenyl]methyl]-, 1,1-dimethylethyl ester(130972-90-6)
• EPA Substance Registry System: Carbamic acid, [[4-(2-bromoethoxy)-3-methoxyphenyl]methyl]-, 1,1-dimethylethyl ester(130972-90-6)

Safety Data

• Hazardous Substances Data: 130972-90-6(Hazardous Substances Data)

Upstream product

• 1196-92-5 Vanillylamin 
• 24424-99-5 di-tert-butyl dicarbonate 
• 130972-89-3 (4-hydroxy-3-methoxybenzyl)carbamic acid tert-butyl ester 
• 7149-10-2 vanillylamine hydrochloride 
• 106-93-4 ethylene dibromide 

Downstream Products

• 130972-91-7 {4-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-ethoxy]-3-methoxy-benzyl}-carbamic acid tert-butyl ester 
• 289903-50-0 tert-butyl N-[4-(2-azidoethoxy)-3-methoxybenzyl]carbamate 
• 289903-56-6 4-(2-azidoethoxy)-3-methoxybenzylisothiocyanate 
• 289903-58-8 2,2-Dimethyl Propionic Acid 2-{3-[4-(2-Azidoethoxy)-3-methoxybenzyl]thioureido Methyl}-3-(3,4-dimethylphenyl)propyl ester 
• 289903-60-2 2,2-Dimethyl Propionic Acid 2-{3-[4-(2-Azidoethoxy)-3-methoxybenzyl]thioureido Methyl}-3-(4-t-butylphenyl)propyl Ester 
• 139693-27-9 4-(2-phthalimidoethoxy)-3-methoxybenzylisothiocyanate 
• 184003-38-1 1-{4-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-ethoxy]-3-methoxy-benzyl}-3-phenethyl-thiourea 

Relevant articles and documents

The SAR analysis of TRPV1 agonists with the α-methylated B-region

A series of TRPV1 agonists with amide, reverse amide, and thiourea groups in the B-region and their corresponding α-methylated analogues were investigated. Whereas the α-methylation of the amide B-region enhanced the binding affinities and potencies as agonists, that of the reverse amide and thiourea led to a reduction in receptor affinity. The analysis indicated that proper hydrogen bonding as well as steric effects in the B-region are critical for receptor binding.

Vanilloid analogues containing resinferatoxin pharmacophores as potent vanilloid receptor agonists and analgesics, compositions and uses thereof

The present invention is related to new vanilloid analogues containing resiniferatoxin pharmacophores, pharmaceutical compositions comprising such analogues, and their uses as vanilloid receptor agonists and potent analgesics. The present invention provides a pharmaceutical composition for treating acute, chronic, inflammatory or neuropathic pains or for treating bladder hypersensitivity.