139721-79-2Relevant academic research and scientific papers
2,3-Dihydro-dithiin and -dithiepine-1,1,4,4-tetroxides: Small molecule non-peptide antagonists of the human galanin hGAL-1 receptor
Scott, Malcolm K.,Ross, Tina M.,Lee, Daniel H. S.,Wang, Hoau-Yan,Shank, Richard P.,Wild, Kenneth D.,Davis, Coralie B.,Crooke, Jeffrey J.,Potocki, Alexander C.,Reitz, Allen B.
, p. 1383 - 1391 (2007/10/03)
The neuropeptide galanin modulates several physiological functions such as cognition, learning, feeding behavior, and depression, probably via the galanin 1 receptor (GAL-R1). Using an HTS assay based on 125I-human galanin binding to the human
Mechanism of the Broensted Acid Catalysed Hydrolysis of 2-Aryl-2-methyl-1,3-dithianes in Aqueous Perchloric acid
Ali, Muhammad,Satchell, Derek P. N.
, p. 219 - 222 (2007/10/02)
The acid catalysed hydrolysis of five para-substituted 2-aryl-2-methyl-1,3-dithianes in aqueous perchloric acid (3-9 mol dm-3) has been studied kinetically.The effect of changes in substituents (ρ = -3.1), temperature (ΔS(excit.) = -38-60 J K-1 mol-1) and acidity (m(excit.) = 0.54-0.74), and the solvent isotope effects (kobsD2O/kobsH2O E2 mechanism for the MeO, Me, H and Cl derivatives.For the p-NO2 compound the acidity dependence, and the values of ΔH(excit.) and ΔS(excit.) (ca. -200 J K-1 mol-1) suggest a change to an A2-like mechanism.Our results are discussed in the light of previous work on acetal hydrolysis.
