13973-23-4Relevant articles and documents
Lipase-Catalyzed Resolution of Chiral 2-Amino 1-Alcohols
Francalanci, Franco,Cesti, Pietro,Cabri, Walter,Bianchi, Daniele,Martinengo, Tiziano,Foa, Marco
, p. 5079 - 5082 (1987)
Lipase-catalyzed resolution of 2-amino 1-alcohols was readily accomplished provided that the amino group was protected as an N-alkoxycarbonyl derivative.Racemic 2-amino-1-butanol and 2-amino-1-propanol were chosen as model compounds, and the resolution was achieved both by hydrolysis of their ester derivatives and by transesterification in ethyl acetate.In either case the (R) enantiomers reacted faster, and at low conversion, the (R) form in high optical purity was obtained as alcohol by hydrolysis and as acetate by transesterification.The two procedures can therefore be considered as complementary with respect to the final product composition.By using commercially available lipase preparations both (R)-(-) and (S)-(+) enantiomers of 2-amino 1-alcohols were isolated in high enantiomeric excesses (95percent).
Modified Mg: Al hydrotalcite in the synthesis of oxazolidin-2-ones
Cwik, Agnieszka,Fuchs, Aliz,Hell, Zoltan,Boejtoes, Ildiko,Halmai, Dora,Bombicz, Petra
, p. 967 - 969 (2007/10/03)
The modified Mg: Al (3: 1) hydrotalcite has been found to be an efficient catalyst in the conversion of carbamates into oxazolidin-2-ones under mild reaction conditions. A wide variety of oxazolidin-2-ones were obtained with excellent chemical yield. The Royal Society of Chemistry 2005.
