1397342-86-7

Upstream product

• 1189-71-5 isocyanate de chlorosulfonyle 
• 100-02-7 4-nitro-phenol 
• 563-79-1 2,3-Dimethyl-2-butene 
• 89692-65-9 N-<<(4-nitrophenyl)oxy>carbonyl>sulfamyl chloride 

Downstream Products

• 1397342-38-9 cyclohexyl-(5,5,6,6-tetramethyl-4,4-dioxo-5,6-dihydro-4H-4λ⁶-[1,4,3]oxathiazin-2-yl)amine 
• 1397342-47-0 [(S)-1-(2-fluorophenyl)ethyl]-(5,5,6,6-tetramethyl-4,4-dioxo-5,6-dihydro-4H-4λ⁶-[1,4,3]oxathiazin-2-yl)amine 
• 1397342-50-5 3-[(S)-3-hydroxy-1-(5,5,6,6-tetramethyl-4,4-dioxo-5,6-dihydro-4H-4λ⁶-[1,4,3]oxathiazin-2-ylamino)propyl]benzonitrile 
• 1397342-56-1 [(S)-1-(2-chlorophenyl)ethyl]-(5,5,6,6-tetramethyl-4,4-dioxo-5,6-dihydro-4H-4λ⁶-[1,4,3]oxathiazin-2-yl)amine 
• 1397342-59-4 (1R,3R)-3-(5,5,6,6-Tetramethyl-4,4-dioxo-5,6-dihydro-4H-4λ6-[1,4,3]oxathiazin-2-ylamino)cyclohexanol 
• 1397342-95-8 (S)-3-(2-chlorophenyl)-3-(5,5,6,6-tetramethyl-4,4-dioxo-5,6-dihydro-4H-4λ*6*-1,4,3-oxathiazin-2-ylamino)propionic acid methyl ester 

Relevant academic research and scientific papers

TETRASUBSTITUTED OXATHIAZINE DERIVATIVES, METHOD FOR PRODUCING THEM, THEIR USE AS MEDICINE AND DRUG CONTAINING SAID DERIVATIVES AND THE USE THEREOF

The invention relates to the compounds of formula (I) and to the physiologically acceptable salts thereof. Said compounds are suitable e.g. for the treatment of hyperglycemia.

DI AND TRI - SUBSTITUTED OXATHIAZINE DERIVATIVES, METHOD FOR THE PRODUCTION, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS MEDICINE AND DRUG CONTAINING SAID DERIVATIVES AND USE THEREOF

The invention relates to compounds of formula (I) and to the physiologically compatible salts thereof. Said compounds are suitable, for example, for treating hyperglycemia.

DI- AND TRI-SUBSTITUTED OXATHIAZINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS MEDICINE AND DRUG CONTAINING SAID DERIVATIVES AND USE THEREOF

The invention relates to compounds of formula (I) and to the physiologically compatible salts thereof. Said compounds are suitable, for example, for treating hyperglycemia.

1,1-Dioxo-5,6-dihydro-[4,1,2]oxathiazines, a novel class of 11?-HSD1 inhibitors for the treatment of diabetes

Racemic cis-1,1-dioxo-5,6-dihydro-[4,1,2]oxathiazine derivative 4a was isolated as an impurity in a sample of a hit from a HTS campaign on 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). After separation by chiral chromatography the 4a-S, 8a-R enantio