139740-92-4Relevant academic research and scientific papers
Synthesis of 4,4'>gramicidin S by Solid-Phase-Synthesis and Cyclization-Cleavage Method with Oxime Resin
Xu, Ming,Nishino, Norikazu,Mihara, Hisakazu,Fujimoto, Tsutomu,Izumiya, Nobuo
, p. 191 - 194 (1992)
Cyclic decapeptide 4,4'>gramicidin S has been efficiently synthesized via stepwise solid-phase-synthesis and cyclization-cleavage with the Kaiser's oxime resin in 45percent total yield.This analog showed the similar conformation to the natural gramicidin S in MeOH.The pyrene ring introduced into the peptide is a useful fluorescent probe for the study of the mechanism of the antimicrobial activity.
