Synthesis of 4,4'>gramicidin S by Solid-Phase-Synthesis and Cyclization-Cleavage Method with Oxime Resin

DOI: 10.1246/cl.1992.191

Source and publish data:

Chemistry Letters p. 191 - 194 (1992)

Update date:2022-08-02

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Authors:

Xu, Ming

Nishino, Norikazu

Mihara, Hisakazu

Fujimoto, Tsutomu

Izumiya, Nobuo

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Article abstract of DOI:10.1246/cl.1992.191

Cyclic decapeptide 4,4'>gramicidin S has been efficiently synthesized via stepwise solid-phase-synthesis and cyclization-cleavage with the Kaiser's oxime resin in 45percent total yield.This analog showed the similar conformation to the natural gramicidin S in MeOH.The pyrene ring introduced into the peptide is a useful fluorescent probe for the study of the mechanism of the antimicrobial activity.

Full text of DOI:10.1246/cl.1992.191

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