139743-08-1

Basic information

• Product Name: (2-AMINO-3-NITRO-PHENYL)-METHANOL
• Synonyms: (2-AMINO-3-NITRO-PHENYL)-METHANOL;2-Amino-3-nitrobenzenemethanol
• CAS NO: 139743-08-1
• Molecular Formula: C₇H₈N₂O₃
• Molecular Weight: 168.15
• Mol File: 139743-08-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 397.3±27.0 °C(Predicted)
• Appearance: /
• Density: 1.432±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 13.67±0.10(Predicted)
• CAS DataBase Reference: (2-AMINO-3-NITRO-PHENYL)-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (2-AMINO-3-NITRO-PHENYL)-METHANOL(139743-08-1)
• EPA Substance Registry System: (2-AMINO-3-NITRO-PHENYL)-METHANOL(139743-08-1)

Safety Data

• Hazardous Substances Data: 139743-08-1(Hazardous Substances Data)

Usage

General Description

(2-AMINO-3-NITRO-PHENYL)-METHANOL is a chemical compound with the molecular formula C7H8N2O4. It is a derivative of phenol with a nitro and an amino group attached to the aromatic ring. (2-AMINO-3-NITRO-PHENYL)-METHANOL is commonly used as an intermediate in the synthesis of various pharmaceuticals and organic compounds. It is known for its potential applications in the field of medicinal chemistry and organic synthesis. Additionally, (2-AMINO-3-NITRO-PHENYL)-METHANOL is also used as a reagent in chemical reactions and as a building block for the preparation of more complex organic molecules. Its structure and properties make it a versatile compound with diverse potential uses in different branches of chemistry.

Upstream product

• 606-18-8 3-nitroanthranilic acid 
• 3970-35-2 2-chloro-3-nitrobezoic acid 

Downstream Products

• 916326-25-5 C₁₁H₁₇N₃O₂ 
• 97271-97-1 2-amino-3-nitrobenzaldehyde 
• 1025886-12-7 C₈H₁₀N₂O₅S 
• 148890-67-9 8-Amino-1,4-dihydro-benzo[d][1,3]oxazin-2-one 
• 148890-66-8 8-Nitro-1,4-dihydro-benzo[d][1,3]oxazin-2-one 
• 148890-70-4 N-(2-amino-3-nitrobenzyl)isopropylamine 
• 1346169-37-6 1-methoxymethyl-2-amino-3-nitrobenzene 
• 916325-86-5 3-(methoxymethyl)benzene-1,2-diamine 
• 874279-69-3 2-(chloromethyl)-6-nitroaniline 

Relevant articles and documents

2-Phenyl-4-piperazinylbenzimidazoles: Orally active inhibitors of the gonadotropin releasing hormone (GnRH) receptor

Antagonism of the gonadotropin releasing hormone (GnRH) receptor has shown positive clinical results in numerous reproductive tissue disorders such as endometriosis, prostate cancer and others. Traditional therapy has been limited to peptide agonists and

High-affinity α-aminobutyric acid A/benzodiazepine ligands: Synthesis and structure - Activity relationship studies of a new series of tetracyclic imidazoquinoxalines

A series of tetracyclic imidazoquinoxaline analogs was developed which constrain the carbonyl group of the partial agonist 3-(5-cyclopropyl-1,2,4- oxadiazol-3-yl)-5-[(dimethylamino)carbonyl]4,5-dihydroimidazo[1,5- a]quinoxaline (2, U-91571) away from the benzene ring. These analogs orient the carbonyl group in the opposite direction of the previously reported full agonist 1-(5-cyclopropyl- 1,2,4-oxadiazol-3-yl)- 12,12a-dihydroimidazo[1,5- a]pyrrolo[2,1-c]quinoxalin- 10(11H)one (3, U-89267). A number of approaches were utilized to form the 'bottom' ring of this tetracyclic ring system including intramolecular cyclizations promoted by Lewis acids or base, as well as metal-carbenoid conditions. The size and substitution pattern of the additional ring was widely varied. Analogs within this series had high affinity for the benzodiazepine receptor on the α-aminobutyric acid A chloride ion channel complex. From TBPS shift and Cl- current assays, the in vitro efficacy of compounds within this class ranged from antagonists to partial agonists with only 18a identified as a full agonist. Additionally, several analogs were quite potent at antagonizing metrazole-induced seizures indicating possible anticonvulsant or anxiolytic activity. Unlike 3, analogs in this series did not have high affinity for the diazepam insensitive α6β2δ2 subtype. These results suggest that either constraining the carbonyl group away from the benzene ring or the greater planarity that results from the additional cyclic structure provides analogs with partial agonist properties and prevents effective interaction with the α6β2δ2 subtype.