6080-56-4

Basic information

• Product Name: Lead acetate trihydrate
• Synonyms: bleiazetat;Leadacetate(II),trihydrate;leadacetate,medicinal;Leaddiacetatetrihydrate;Normalleadacet-ate;PLATINIZING SOLUTION;PLATINIZING SOLUTION, ASTM;Lead Acetate Trihydrate BPC
• CAS NO: 6080-56-4
• Molecular Formula: C₄H₆O₄Pb*3H₂O
• Molecular Weight: 379.33
• EINECS: 206-104-4
• Product Categories: Analytical Reagents for General Use;E-L, Puriss p.a. ACS;Puriss p.a. ACS;Catalysis and Inorganic Chemistry;Chemical Synthesis;Lead;Micro/Nanoelectronics;Solution Deposition Precursors;ACS GradeChemical Synthesis;Essential Chemicals;Routine Reagents;metal acetate salt;Lead Salts;Materials Science;Metal and Ceramic Science;Salts;Solution Deposition Precursors
• Mol File: 6080-56-4.mol
• Article Data: 0

Chemical Properties

• Melting Point: 75 °C (dec.)(lit.)
• Boiling Point: 280°C
• Flash Point: 40 °C
• Appearance: White or colorless, efflorescent/Solid
• Density: 2,55 g/cm3
• Vapor Pressure: 13.9mmHg at 25°C
• Storage Temp.: 2-8°C
• Solubility: 443g/l
• Water Solubility: 625 g/L
• Merck: 14,5397
• BRN: 3730298
• CAS DataBase Reference: Lead acetate trihydrate(CAS DataBase Reference)
• NIST Chemistry Reference: Lead acetate trihydrate(6080-56-4)
• EPA Substance Registry System: Lead acetate trihydrate(6080-56-4)

Safety Data

• Hazard Codes: T,N
• Statements: 61-33-48/22-50/53-62
• Safety Statements: 53-45-60-61
• RIDADR: UN 1616 6.1/PG 3
• WGK Germany: 2
• RTECS: OF8050000
• TSCA: Yes
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 6080-56-4(Hazardous Substances Data)

Usage

Chemical Properties

Different sources of media describe the Chemical Properties of 6080-56-4 differently. You can refer to the following data:
1. White Crystals
2. Lead acetate trihydrate (plumbous acetate trihydrate), Pb(C2H3O2)2·3H2O, is a white, monoclinic crystalline solid; some physical properties are given in Table 2. Upon heating it loses some of its water of crystallization, and after melting, decomposes at 200 °C. The trihydrate is highly soluble in water but insoluble in ethyl alcohol. It has an intensely sweet taste, hence it is sometimes called sugar of lead, but it is poisonous. The trihydrate is made by dissolving lead monoxide in hot dilute acetic acid solution; on cooling, large crystals separate, sometimes up to 60-cm long.

Uses

Different sources of media describe the Uses of 6080-56-4 differently. You can refer to the following data:
1. Lead(II) acetate trihydrate is used as a mordant in textile printing and dyeing, drier in paints, varnishes and as a water repellant. It is also used in cosmetics and to prepare other lead compounds. It serves as an ingredient in progressive types of hair coloring dyes. Further, it is used in the detection of poisonous gas hydrogen sulfide.
2. Lead(II) acetate trihydrate was a component of the solution which was used towards the fabrication of platinum black microelectrodes. Lead acetate trihydrate may be used in the manufacturing of other lead salts. It may be used in the textile industry for dyeing and printing. In paint industry, lead acetate acts as a drying agent and as a purification agent in chemical synthesis.
3. Lead acetate trihydrate, the usual commercial form, is used in the preparation of basic lead carbonate and lead chromate, as a mordant in cotton dyes, as a reagent for the manufacture of lead salts of higher fatty acids, as a water repellant, as a component in combined toning and fixing baths for daylight printing papers, and as a means of treating awnings and outdoor furniture to prevent removal of mildew- and rotproofing agents by rain or laundering. Other uses include preparation of rubber antioxidants; processing agent in the cosmetic, perfume, and toiletry industries; component of coloring agents for adhesives; and preparation of organic lead soaps as driers of paints and inks.

General Description

White powder or white chunky solid. Slight odor. pH (5% aqueous solution at 77°F) 5.5-6.5.

Air & Water Reactions

Slowly effloresces in air. Water soluble but solutions absorb carbon dioxide from the air and to give incompletely soluble products.

Reactivity Profile

Lead acetate trihydrate may react with acids and oxidizing agents. Is incompatible with sulfates, citrates, tartrates, chlorides, carbonates, alkalis, tannin, resorcinol, salicylic acid, phenol, chloral hydrate, sulfites, vegetable infusions and tinctures. Incompatible with phosphates . Incompatible with KBrO3 and with EDTA.

Fire Hazard

Literature sources indicate that Lead acetate trihydrate is nonflammable.

InChI:InChI=1/2C2H4O2.3H2O.Pb/c2*1-2(3)4;;;;/h2*1H3,(H,3,4);3*1H2;

Synthetic route

water (7732-18-5) + acetic acid (64-19-7) + lead(II) chloride → lead(II) acetate trihydrate (6080-56-4)

Conditions	Yield
With sodium carbonate In acetic acid preparation of PbCO3 by treatment of PbCl2 with 1.5fold excess Na2CO3, treatment with acetic acid;;	86.5%
With Na2CO3 In acetic acid aq. acetic acid; preparation of PbCO3 by treatment of PbCl2 with 1.5fold excess Na2CO3, treatment with acetic acid;;	86.5%

acetic acid (64-19-7) → lead(II) acetate trihydrate (6080-56-4)

Conditions	Yield
With lead
With lead(II) oxide
With lead; air

water (7732-18-5) + lead(II) oxide + acetic acid (64-19-7) → lead(II) acetate trihydrate (6080-56-4)

Conditions	Yield
In acetic acid 20% acetic acid, 380°C, stirring until a pH of 5.5 results, treatment of soln. with activated coal, further treatment at 30°C with activated coal and salicylic acid, thiosalicylic acid or thiocyanates;; product contains less than 5E-6% Fe(3+);;
In acetic acid aq. acetic acid; dissolving PbO in dild. acetic acid;;
In acetic acid aq. acetic acid; 20% acetic acid, 380°C, stirring until a pH of 5.5 results, treatment of soln. with activated coal, further treatment at 30°C with activated coal and salicylic acid, thiosalicylic acid or thiocyanates;; product contains less than 5E-6% Fe(3+);;

water (7732-18-5) + lead(II) oxide + ethyl acetate (141-78-6) → lead(II) acetate trihydrate (6080-56-4)

Conditions	Yield
In ethyl acetate treatment with ethyl acetate in presence of H2O;;
In ethyl acetate treatment with ethyl acetate in presence of H2O;;

lead (7439-92-1) + water (7732-18-5) + acetic acid (64-19-7) → lead(II) acetate trihydrate (6080-56-4)

Conditions	Yield
With air In acetic acid aq. acetic acid; treatment of Pb with aq. acetic acid in presence of air;;

lead(II) sulfate + water (7732-18-5) + acetic acid (64-19-7) → lead(II) acetate trihydrate (6080-56-4)

Conditions	Yield
With sodium hydroxide In acetic acid separation of sulfate with hot NaOH, react. with acetic acid;;
With NaOH In acetic acid aq. acetic acid; separation of sulfate with hot NaOH, react. with acetic acid;;

lead monoxide + water (7732-18-5) + acetic acid (64-19-7) → lead(II) acetate trihydrate (6080-56-4)

Conditions	Yield
In acetic acid dissolving in hot dild. acetic acid, crystn. on cooling;;
In acetic acid aq. acetic acid; dissolving in hot dild. acetic acid, crystn. on cooling;;

lead(II) carbonate (790616-79-4) + water (7732-18-5) + acetic acid (64-19-7) → lead(II) acetate trihydrate (6080-56-4)

Conditions	Yield
In acetic acid
In acetic acid aq. acetic acid;

lead(II) sulfate + sodium acetate (127-09-3) → lead(II) acetate trihydrate (6080-56-4)

Conditions	Yield
In water
In water with concd. alk. acetate soln. at 25°C;;
In water with concd. alk. acetate soln. at 25°C;;
In water

ammonium acetate + lead(II) sulfate → lead(II) acetate trihydrate (6080-56-4)

Conditions	Yield
In water
In water

lead(II) acetate trihydrate (6080-56-4) → water (7732-18-5)

Conditions	Yield
In neat (no solvent) over H2SO4 in 7d;;	100%
In neat (no solvent) loss of 3mol H2O in vac. over BaO;;
In neat (no solvent) complete loss of H2O in vac. over H2SO4 within 8d at 0°C, in 2d at 22°C;;	>99

lead(II) acetate trihydrate (6080-56-4) + (1,1’-(pyridine-2,6-diyl)bis(ethan-1-yl-1-ylidene))dibenzohydrazine (73818-26-5) → C23H19N5O2(2-)*Pb(2+)

Conditions	Yield
With triethylamine In methanol for 2h;	99%

lead(II) acetate trihydrate (6080-56-4) + (1,2-bis(3,5-di(t-butyl)-2-mercaptophenylthio)ethane)-H2 → {Pb(1,2-bis(3,5-di(t-butyl)-2-mercaptophenylthio)ethane)(2-)} (126859-18-5)

Conditions	Yield
With C4H9Li In methanol under N2, BuLi added to t-bu-S4-H2 in THF at -78°C, warmed to 25°C, solvent removed, CH3OH added, solution added to Pb(CH3COO)2 in CH3OH, stirred for 2 h; filtered, washed (cold CH3OH), dried in vacuo for 12 h; elem. anal., NMR, mass spectroscopy;	98%

ammonium diphenyldithiophosphinate (34669-05-1) + lead(II) acetate trihydrate (6080-56-4) → bis(diphenyldithiophosphinato)lead(II) (154425-85-1)

Conditions	Yield
In water aq. solns. of starting materials are mixed, stirring at room temp. for 15 min; filtn. under vac., washing several times with distilled H2O and EtOH, vac. drying, recrystn. from hot benzene, elem. anal.;	98%

azelaic acid (123-99-9) + lead(II) acetate trihydrate (6080-56-4) → lead(II) azelate (7717-58-0, 14489-30-6, 25725-29-5, 87720-72-7)

Conditions	Yield
In water High Pressure; placed in a bomb, heated to 220°C (3 h), held for 3 h; cooled to room temp. (3 h), crysts., washed (water), air dried; elem. anal.;	96%

lead(II) acetate trihydrate (6080-56-4) + 1-phenyl-3-methyl-4-butyryl-pyrazolone-5 → bis(1-phenyl-3-methyl-4-butanoyl pyrazolonato)lead(II)

Conditions	Yield
In ethanol; water addn. of aq. Pb(OAc)2 to 2 equiv. ligand (in EtOH) at 45°C, stirring overnight; collection (filtration), washing (water), recrystn. (aq. EtOH), drying in air; elem. anal.;	96%

lead(II) acetate trihydrate (6080-56-4) + 1-phenyl-3-methyl-4-butyryl-pyrazolone-5 → Pb(2+)*2(C6H5)(CH3)C3N2(O)C(O)CH2CH2CH3(1-)=PbC28H30O4N4

Conditions	Yield
In ethanol; water byproducts: H(1+); addn. of warm (50°C) aq. soln. of PbOAc to warm soln. of phenylpyrazolone in EtOH (stirring), stirring (45°C, a few minutes; pptn.); filtration, washing (water), recrystn.(aq. EtOH), air drying; elem. anal.;	96%

lead(II) acetate trihydrate (6080-56-4) + 3,5-di(t-butyl)benzene-1,2-dithiolate (109082-03-3) → {Pb(3,5-di(t-butyl)benzene-1,2-dithiolate)(2-)} (126828-86-2)

Conditions	Yield
With NaOCH3 In methanol byproducts: CH3COO(1-); under N2, t-bu-S2-H2 in MeOH and NaOMe in MeOH added to Pb(CH3COO)2 in MeOH at 25°C; filtered after 2 h, washed (MeOH), dried in vacuo for 12 h; elem. anal.,NMR, mass spectroscopy;	95%

{N,N'-propane-1,3-diylbis(3-formyl-5-methylsalicylideneiminato)}copper(II) + lead(II) acetate trihydrate (6080-56-4) + 1,4-diaminobutane (110-60-1) → {Pb(Cu(C6H2(CH3)(O)(CHN)2)2(CH2)3(CH2)4)2}(2+)*2B(C6H5)4(1-)

Conditions	Yield
With NaB(C6H5)4 In methanol; N,N-dimethyl-formamide N,N'-propane-1,3-diylbis(3-formyl-5-methylsalicylideneiminato)copper(II) and lead(II) acetate in hot dmf, stirring at 25°C 10 min., then with butane-1,4-diamine in methanol at 25°C for 30 min; washed with methanol and ether, dried in air, elem. anal.;	95%

lead(II) acetate trihydrate (6080-56-4) + 1,5-naphthyridine-4,8-diol (28312-61-0) → Pb(2+)*C8H4N2O2(2-) = Pb(C8H4N2O2) (73849-11-3)

Conditions	Yield
With sodium carbonate In water organic compound dissolved in warm water by addn. of Na2CO3, soln. added to aq. soln. of Pb(CH3COO)2*3H2O; precipitate collected after several hours, washed with water, dried over P2O5 in vacuo at room temp., ground to powder, elem. anal.;	95%

lead(II) acetate trihydrate (6080-56-4) + 1,10-bis<1-phenyl-3-methyl-5-hydroxy-4-pyrazolyl>-1,10-decanedione → Pb(C30H32O4N4)

Conditions	Yield
In ethanol; water ppt. boiling iu aq. EtOH, air-drying; elem. anal.;	95%

α-mercapto-β-(2-furyl) acrylic acid (19334-19-1) + lead(II) acetate trihydrate (6080-56-4) → lead 3-(2-furyl)-2-sulfanylpropenoate

Conditions	Yield
In ethanol; water for 1h;	95%

3-(4-methoxyphenyl)-2-sulfanylpropenoic acid (93515-30-1, 5740-35-2) + lead(II) acetate trihydrate (6080-56-4) → C10H8O3S(2-)*Pb(2+)

Conditions	Yield
In ethanol; water	95%

5,15-dioxo-10,20-bis(3,5-di-tert-butylphenyl)porphodimethene + lead(II) acetate trihydrate (6080-56-4) → C48H50N4O2Pb

Conditions	Yield
In methanol; chloroform at 25℃; for 1.5h;	95%

1,6-bis(5-hydroxy-1-phenyl-3-methyl-1H-pyrazol-4-yl)hexane-1,6-dione (188951-49-7) + lead(II) acetate trihydrate (6080-56-4) → Pb(C26H24O4N4)

Conditions	Yield
In ethanol; water ppt. boiling iu aq. EtOH, air-drying; elem. anal.;	94%

lead(II) acetate trihydrate (6080-56-4) + glycerol (56-81-5) → lead(II) glycerolate

Conditions	Yield
With sodium hydroxide In water at 140℃; for 0.0833333h;	94%

2.6-bis(hydroxymethyl)pyridine (1195-59-1) + lead(II) acetate trihydrate (6080-56-4) + saccharin (81-07-2) → [Pb(saccharine)2(pyridine-2,6-dimethanol)]

Conditions	Yield
In water aq. soln. of Pb salt added to warm aq. mixt. of org. compds.; volume reduced, crystd. at room temp., filtered, dried in air, elem. anal.;	93%

N,N'-bis-(2-mercaptoethyl)isophthalamide (351994-94-0) + lead(II) acetate trihydrate (6080-56-4) → C6H4(CONHCH2CH2S)2Pb (934468-82-3)

Conditions	Yield
In ethanol; water aq. soln. Pb(OAc)2*3H2O was added to soln. ligand in EtOH; ppt. was filtered and dried in vacuo; elem. anal.;	93%

lead(II) acetate trihydrate (6080-56-4) + lead(II) oxide → basic lead acetate

Conditions	Yield
In ethanol; water High Pressure; (N2); Pb(OAc)2*3H2O was dissolved in H2O-EtOH (3:2), PbO was added, resulting slurry was sonicated for 20 min, heated in vessel at 120°C for 12 h, cooled to room temp.; supernatant was removed, dried in vac. without heating in Abderhalden drying pistol for 12 h;	93%
In water High Pressure; (N2); Pb(OAc)2*3H2O was dissolved in H2O, PbO was added, resulting slurry was sonicated for 20 min, heated in vessel at 120°C for 12 h, cooled to room temp.; supernatant was removed, dried in vac. without heating in Abderhalden drying pistol for 12 h, elem. anal.;	41%

lead(II) acetate trihydrate (6080-56-4) + 3-ethyl-1-methyl-1H-imidazol-3-ium bromide (65039-08-9) → 1-ethyl-3-methylimidazolium acetate (143314-17-4)

Conditions	Yield
In water at 35℃; for 48h; Inert atmosphere;	93%
In methanol; water
In methanol; water

(4-fluorophenyl)-2-mercaptoacrylic acid (29529-79-1) + lead(II) acetate trihydrate (6080-56-4) → C9H5FO2S(2-)*Pb(2+)

Conditions	Yield
In ethanol; water for 3h;	93%

2-Hydroxymethylpyridine (586-98-1) + lead(II) acetate trihydrate (6080-56-4) + saccharin (81-07-2) → [Pb(saccharine)2(2-pyridylmethanol)] (454658-48-1)

Conditions	Yield
In water aq. soln. of Pb salt added to warm aq. mixt. of org. compds.; volume reduced, crystd. at room temp., filtered, dried in air, elem. anal.;	92%

lead(II) acetate trihydrate (6080-56-4) + 1,2-bis(2-mercaptophenylthio)ethane (83209-89-6) → {Pb(1,2-bis(2-mercaptophenylthio)ethane)(2-)} (126859-23-2)

Conditions	Yield
With NaOCH3 In methanol under N2, NaOMe in MeOH and S4-H2 in MeOH added to Pb(CH3COO)2 in MeOH, stirred for several h at 25°C; filtered, washed (CH3OH), dried in vacuo for 12 h; elem. anal., NMR, mass spectroscopy;	91%

1,8,15,22-tetrakis(pentan-3'-yloxy)phthalocyanine (183481-14-3) + lead(II) acetate trihydrate (6080-56-4) → [1,8,15,22-tetrakis(3-pentyloxy)phthalocyaninate]Pb(II) (807614-14-8)

Conditions	Yield
In pentan-1-ol mixt. of Pb compd. and ligand in n-pentanol was heated at 140°C for 8 h under N2; solvent removed (vac.); chromd. (silica gel, CHCl3); recrystd. (CHCl3/MeOH); elem. anal.;	91%

lead(II) acetate trihydrate (6080-56-4) + 3-methyl-1-phenyl-4-valeroyl-pyrazol-5-one → Pb(2+)*2(C6H5)(CH3)C3N2(O)C(O)CH2CH2CH2CH3(1-)=PbC30H34O4N4

Conditions	Yield
In ethanol; water byproducts: H(1+); addn. of warm (50°C) aq. soln. of PbOAc to warm soln. of phenylpyrazolone in EtOH (stirring), stirring (45°C, a few minutes; pptn.); filtration, washing (water), recrystn.(aq. EtOH), air drying; elem. anal.;	91%

benzene-1,4-dithiol (624-39-5) + lead(II) acetate trihydrate (6080-56-4) + 1,5-diamino-3-azapentane (111-40-0) → [Pb(1,4-benzenedithiolato)(diethylenetriamine)]n (1350615-40-5)

Conditions	Yield
In further solvent(s) (N2); heating a suspn. of metal salt and dithiol in diethylenetriamine to 130°C for 16 h, cooling to room temp.; filtration, washing ppt. with methanol, Et2O; elem. anal.;	91%

2',2'',2''',2'''-(benzene-1,2,4,5-tetrayl)tetrakis(1,1,3,3-tetramethylguanidine) (1117964-61-0) + lead(II) acetate trihydrate (6080-56-4) → C34H62N12O8Pb2

Conditions	Yield
In ethanol at 20℃; for 2h; Inert atmosphere; Schlenk technique;	91%

1,10-Phenanthroline (66-71-7) + p-Coumaric Acid (7400-08-0) + lead(II) acetate trihydrate (6080-56-4) + N,N-dimethyl-formamide (68-12-2, 33513-42-7) → [Pb(trans-4-hydroxycinnamic acid(-1H))2(phen)(DMF)]2

Conditions	Yield
In neat (no solvent, solid phase) grinding of Pb(CH3COO)2*3H2O, trans-4-hydroxycinnamic acid in solid state at room temp.; dissolving in DMF soln.; filtration, evapn. at room temp.; elem. anal.;	90%

5,10,15,20-tetrakis-triisopropylsilylethynylporphyrin + lead(II) acetate trihydrate (6080-56-4) → [5,10,15,20-tetrakis-triisopropylsilylethynylporphyrinato]lead(II) (202524-84-3)

Conditions	Yield
In N,N-dimethyl-formamide mixed, refluxed for 2 h; crystd.(water), filtered, washed (water, CH3OH), recrystd.(DCM-CH3OH), elem. anal., XRD, IR, UV, MAS;	90%

diselenodipropionic acid dimethyl ester (136397-82-5) + lead(II) acetate trihydrate (6080-56-4) → Pb(2+)*2SeCH2CH2C(O)OCH3(1-)=[Pb(SeCH2CH2C(O)OCH3)2]

Conditions	Yield
With NaBH4 In methanol MeOH soln. of NaBH4 (1.27 mmol) added to MeOH soln. of ligand (0.57 mmol), stirred for 5 min, MeOH soln. of Pb compd. (0.56 mmol) added with stirring at room temp. under N2, mixt. stirred for 3 h; evapd., washed (cold hexane), extd. (CH2Cl2), filtered, evapd. (vac.), recrystd. (CH2Cl2/hexane), elem. anal.;	90%

Upstream product

• 64-19-7 acetic acid 
• 7732-18-5 water 
• 141-78-6 ethyl acetate 
• 7439-92-1 lead 
• 790616-79-4 lead(II) carbonate 
• 7758-95-4 lead(II) chloride 
• 127-09-3 sodium acetate 
• 92206-38-7 ammonium acetate 
• 546-67-8 lead(IV) tetraacetate 

Downstream Products

• 6598-47-6 1,2-diacetyl-4-phenyl-1,2,4-triazolidine-3,5-dione 
• 10101-63-0 lead(II) iodide 
• 301-04-2 lead acetate 
• 7428-48-0 lead(II) stearate 
• 126828-86-2 {Pb(3,5-di(t-butyl)benzene-1,2-dithiolate)^(2-)} 
• 7717-47-7 lead palmitate 
• 135107-52-7 {IrCl(CO)Pb(CH₃CO₂)(P(C₆H₅)2CH₂(N((CH₂)2O)2(CH₂)2N(CH₂P(C₆H₅)2)((CH₂)2O)2(CH₂)2))}⁽¹⁺⁾*CH₃CO₂^(1-) 
• 102525-55-3 Pb((C₂H₅)2AsC₆H₄COO)2(H₂O)2 
• 220336-25-4 (pyridine)tetraphenylporphinelead diacetate