1398044-50-2 Usage
Uses
Used in Drug Delivery Systems:
Thio-PEG2-t-butyl ester is used as a carrier molecule for drug delivery due to its biocompatibility and the ability to control the release of the thiol group in biological environments. This feature is particularly advantageous for targeted drug delivery, where the release of the active pharmaceutical ingredient can be triggered at specific sites within the body.
Used in Bioconjugation:
In the field of bioconjugation, Thio-PEG2-t-butyl ester serves as a linking agent to covalently bind biological molecules such as proteins, peptides, or nucleic acids to other molecules or surfaces. The presence of the thiol group allows for stable and specific conjugation, which is essential for the development of biosensors, diagnostic tools, and therapeutic agents.
Used in Materials Science:
Thio-PEG2-t-butyl ester is utilized as a component in the development of new materials with tailored properties. Its ability to form covalent bonds and its compatibility with biological systems make it suitable for creating biocompatible coatings, hydrogels, and other materials for use in medical devices, tissue engineering, and regenerative medicine.
Used in Pharmaceutical Development:
In the pharmaceutical industry, Thio-PEG2-t-butyl ester is used as a modifying agent to improve the solubility, stability, and bioavailability of drug candidates. Its incorporation into drug molecules can enhance their pharmacokinetic and pharmacodynamic properties, potentially leading to more effective and safer medications.
Overall, Thio-PEG2-t-butyl ester's unique combination of a reactive thiol group, a biocompatible PEG chain, and a removable t-butyl ester group positions it as a multifunctional compound with broad applications across various industries, particularly in the life sciences and medicine.
Check Digit Verification of cas no
The CAS Registry Mumber 1398044-50-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,9,8,0,4 and 4 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1398044-50:
(9*1)+(8*3)+(7*9)+(6*8)+(5*0)+(4*4)+(3*4)+(2*5)+(1*0)=182
182 % 10 = 2
So 1398044-50-2 is a valid CAS Registry Number.
1398044-50-2Relevant academic research and scientific papers
Chang, Tsung-Che,Manabe, Yoshiyuki,Fujimoto, Yukari,Ohshima, Shino,Kametani, Yoshie,Kabayama, Kazuya,Nimura, Yuka,Lin, Chun-Cheng,Fukase, Koichi
, p. 8219 - 8224 (2018)
Sialyl-Tn (STn) is a tumor-associated carbohydrate antigen (TACA) rarely observed on healthy tissues. We synthesized two fully synthetic N-acetyl and N-propionyl STn trimer (triSTn) vaccines possessing a T-helper epitope and a TLR2 agonist, since the clustered STn antigens are highly expressed on many cancer cells. Immunization of both vaccines in mice induced the anti-triSTn IgG antibodies, which recognized triSTn-expressing cell lines PANC-1 and HepG2. The N-propionyl triSTn vaccine induced the triSTn-specific IgGs, while IgGs induced by the N-acetyl triSTn vaccine were less specific. These results illustrated that N-propionyl triSTn is a valuable unnatural TACA for anticancer vaccines.
