1398044-50-2 Usage
General Description
Thio-PEG2-t-butyl ester is a chemical compound consisting of a thiol group, a polyethylene glycol (PEG) chain with two repeating units, and a t-butyl ester functional group. The thiol group is a sulfur-containing compound that can react with other molecules to form covalent bonds, making it useful in various chemical reactions and as a building block for larger compounds. The PEG chain provides water solubility and biocompatibility, making the compound suitable for use in biological and pharmaceutical applications. The t-butyl ester functional group can be easily removed under mild conditions, allowing for the controlled release of the thiol group in specific biological environments. Overall, Thio-PEG2-t-butyl ester is a versatile compound with potential uses in drug delivery, bioconjugation, and materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 1398044-50-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,9,8,0,4 and 4 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1398044-50:
(9*1)+(8*3)+(7*9)+(6*8)+(5*0)+(4*4)+(3*4)+(2*5)+(1*0)=182
182 % 10 = 2
So 1398044-50-2 is a valid CAS Registry Number.
1398044-50-2Relevant articles and documents
Syntheses and Immunological Evaluation of Self-Adjuvanting Clustered N-Acetyl and N-Propionyl Sialyl-Tn Combined with a T-helper Cell Epitope as Antitumor Vaccine Candidates
Chang, Tsung-Che,Manabe, Yoshiyuki,Fujimoto, Yukari,Ohshima, Shino,Kametani, Yoshie,Kabayama, Kazuya,Nimura, Yuka,Lin, Chun-Cheng,Fukase, Koichi
, p. 8219 - 8224 (2018)
Sialyl-Tn (STn) is a tumor-associated carbohydrate antigen (TACA) rarely observed on healthy tissues. We synthesized two fully synthetic N-acetyl and N-propionyl STn trimer (triSTn) vaccines possessing a T-helper epitope and a TLR2 agonist, since the clustered STn antigens are highly expressed on many cancer cells. Immunization of both vaccines in mice induced the anti-triSTn IgG antibodies, which recognized triSTn-expressing cell lines PANC-1 and HepG2. The N-propionyl triSTn vaccine induced the triSTn-specific IgGs, while IgGs induced by the N-acetyl triSTn vaccine were less specific. These results illustrated that N-propionyl triSTn is a valuable unnatural TACA for anticancer vaccines.
