1398636-08-2

Usage

Structure

Heterocyclic aromatic amine with a bromine atom and an aminophenyl group attached to a pyridine ring

Application

Used in medicinal chemistry as a building block for the synthesis of various pharmaceuticals and biologically active molecules
Potential applications in materials science and organic synthesis

Specific Uses

Building block for drug synthesis
Component in the development of pharmaceuticals
Ingredient in the creation of biologically active compounds

Properties

Aromaticity due to the presence of the pyridine ring
Bromine substitution enhances reactivity and alters chemical properties
Amine group allows for interactions in biological systems

Potential Benefits

Diverse applications due to its versatile chemical structure
Enables the creation of tailored molecules for specific purposes
Facilitates the exploration of new therapeutic agents and materials

Upstream product

• 1072-97-5 5-bromo-2-pyridylamine 
• 1616981-13-5 (E)-5-bromo-2-((4-chlorophenyl)diazenyl)pyridine 
• 65295-93-4 (E)-5-bromo-2-(phenyldiazenyl)pyridine 
• 586-96-9 Nitrosobenzene 
• 381233-96-1 2-amino-3-iodo-5-bromopyridine 
• 214360-73-3 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline 

Downstream Products

• 1449300-75-7 3-(4-aminophenyl)-5-(3,4-dimethoxyphenyl)pyridin-2-amine 
• 1449301-21-6 N-[4-(2-amino-5-bromopyridin-3-yl)phenyl]-5-(4-fluorophenyl)-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydropyridine-3-carboxamide 
• 1449300-25-7 N-[4-(2-amino-5-{4-[(2R)-1,4-dioxan-2-ylmethoxy]-3-methoxyphenyl}pyridin-3-yl)phenyl]-1-ethyl-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide 
• 1449299-72-2 N-{4-[2-amino-5-(3,4-dimethoxyphenyl)pyridin-3-yl]phenyl}-5-(4-fluorophenyl)-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydropyridine-3-carboxamide 
• 1449299-70-0 N-{4-[2-amino-5-(3,4-dimethoxyphenyl)pyridin-3-yl]phenyl}-1-(2-fluoroethyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide 
• 1449299-69-7 N-{4-[2-amino-5-(3,4-dimethoxyphenyl)pyridin-3-yl]phenyl}-5-(4-fluorophenyl)-1-(2-hydroxyethyl)-4-oxo-1,4-dihydropyridine-3-carboxamide 
• 1449299-67-5 N-{4-[2-amino-5-(3,4-dimethoxyphenyl)pyridin-3-yl]phenyl}-5-(4-fluorophenyl)-4-oxo-1-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-1,4-dihydropyridine-3-carboxamide 
• 1449299-66-4 N-{4-[2-amino-5-(3,4-dimethoxyphenyl)pyridin-3-yl]phenyl}-5-(4-fluorophenyl)-1-(2-methoxyethyl)-4-oxo-1,4-dihydropyridine-3-carboxamide 
• 1449299-65-3 N-{4-[2-amino-5-(3,4-dimethoxyphenyl)pyridin-3-yl]phenyl}-5-(4-fluorophenyl)-4-oxo-1-(propan-2-yl)-1,4-dihydropyridine-3-carboxamide 
• 1449300-67-7 N-{4-[2-amino-5-(3-hydroxy-4-methoxyphenyl)pyridin-3-yl]phenyl}-5-(4-fluorophenyl)-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydropyridine-3-carboxamide 
• 1449300-57-5 N-[4-(6-amino-2'-methyl-3,4'-bipyridin-5-yl)phenyl]-1-(2-fluoroethyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide 
• 1449299-63-1 N-{4-[2-amino-5-(3,4-dimethoxyphenyl)pyridin-3-yl]phenyl}-1-ethyl-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide 
• 1449300-41-7 N-{4-[2-amino-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-3-yl]phenyl}-1-(2-fluoroethyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide 
• 1449301-44-3 tert-butyl 4-(4-[6-amino-5-[4-({[1-(2-fluoroethyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridin-3-yl]carbonyl}amino)phenyl]pyridin-3-yl]-1H-pyrazol-1-yl)piperidin-1-carboxylate 

Relevant academic research and scientific papers

TAM family kinase and/or CSF1R kinase inhibitor and application thereof

The invention provides a novel inhibitor compound shown in a general formula (I). The compound has good kinase inhibition activity and can be used for preventing and/or treating diseases mediated by abnormal expression of TAM family kinase and/or a ligand thereof. The compound can target CSF1R kinase and can be used for preventing and/or treating diseases mediated by abnormal expression of a TAM family kinase receptor and/or a CSF1R kinase receptor and/or ligands thereof.

Improved synthesis of pyridyl-biaryl ring systems via benzidine rearrangements

The acid-catalyzed benzidine rearrangement of diazo compounds is known to involve several rearrangements with the major pathway being a [5,5] sigmatropic rearrangement to provide 4,4′-diaminobiaryls. A limitation of this rearrangement has been poor conversions with pyridyl systems. Herein, we address this long standing issue to furnish hetero-biaryls via a pyridinium salt in the presence of trimethylsilyl iodide.

Pyridone Derivatives

Novel compounds or salts thereof, or crystals thereof, which inhibit Axl and are useful for treating diseases caused by Axl hyperfunction, diseases associated with Axl hyperfunction and/or diseases accompanied by Axl hyperfunction are provided. Pyridone derivatives represented by the formula (1) having various substituents or salts thereof, or crystals thereof (where R1, R2, R3, R5, R6, A, W, X and n in the formula (1) are as defined in the specification, respectively) are provided.