1449300-75-7

Upstream product

• 1398636-08-2 3-(4-aminophenyl)-5-bromopyridine-2-amine 
• 365564-10-9 2-(3,4-dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 1072-97-5 5-bromo-2-pyridylamine 
• 381233-96-1 2-amino-3-iodo-5-bromopyridine 
• 214360-73-3 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline 

Downstream Products

• 1449299-75-5 N-{4-[2-amino-5-(3,4-dimethoxyphenyl)pyridin-3-yl]phenyl}-1-(4-fluorobenzyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide 
• 1449299-76-6 N-{4-[2-amino-5-(3,4-dimethoxyphenyl)pyridin-3-yl]phenyl}-5-(4-fluorophenyl)-4-oxo-1-(pyridin-2-ylmethyl)-1,4-dihydropyridine-3-carboxamide 
• 1449299-80-2 N-{4-[2-amino-5-(3,4-dimethoxyphenyl)pyridin-3-yl]phenyl}-1-[(2S)-1,4-dioxan-2-ylmethyl]-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide 
• 1449299-82-4 N-{4-[2-amino-5-(3,4-dimethoxyphenyl)pyridin-3-yl]phenyl}-5-(4-fluorophenyl)-1-[2-(methylamino)-2-oxoethyl]-4-oxo-1,4-dihydropyridine-3-carboxamide 
• 1449299-84-6 N-{4-[2-amino-5-(3,4-dimethoxyphenyl)pyridin-3-yl]phenyl}-1-[2-(dimethylamino)-2-oxoethyl]-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide 
• 1449299-86-8 N-{4-[2-amino-5-(3,4-dimethoxyphenyl)pyridin-3-yl]phenyl}-1-(2,2-difluoro-2-methoxyethyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide 
• 1449299-87-9 N-{4-[2-amino-5-(3,4-dimethoxyphenyl)pyridin-3-yl]phenyl}-1-ethyl-4-oxo-5-phenyl-1,4-dihydropyridine-3-carboxamide 
• 1449299-88-0 N-{4-[2-amino-5-(3,4-dimethoxyphenyl)pyridin-3-yl]phenyl}-1-(2-fluoroethyl)-4-oxo-5-phenyl-1,4-dihydropyridine-3-carboxamide 
• 1449299-59-5 N-{4-[2-amino-5-(3,4-dimethoxyphenyl)pyridin-3-yl]phenyl}-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide 
• 1449299-61-9 N-{4-[2-amino-5-(3,4-dimethoxyphenyl)pyridin-3-yl]phenyl}-5-(4-fluorophenyl)-1-methyl-4-oxo-1,4-dihydropyridine-3-carboxamide 
• 1449299-63-1 N-{4-[2-amino-5-(3,4-dimethoxyphenyl)pyridin-3-yl]phenyl}-1-ethyl-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide 
• 1449299-65-3 N-{4-[2-amino-5-(3,4-dimethoxyphenyl)pyridin-3-yl]phenyl}-5-(4-fluorophenyl)-4-oxo-1-(propan-2-yl)-1,4-dihydropyridine-3-carboxamide 
• 1449299-78-8 N-{4-[2-amino-5-(3,4-dimethoxyphenyl)pyridin-3-yl]phenyl}-5-(4-fluorophenyl)-4-oxo-1-(pyridin-4-ylmethyl)-1,4-dihydropyridine-3-carboxamide 
• 1449299-66-4 N-{4-[2-amino-5-(3,4-dimethoxyphenyl)pyridin-3-yl]phenyl}-5-(4-fluorophenyl)-1-(2-methoxyethyl)-4-oxo-1,4-dihydropyridine-3-carboxamide 

Relevant academic research and scientific papers

TAM family kinase and/or CSF1R kinase inhibitor and application thereof

The invention provides a novel inhibitor compound shown in a general formula (I). The compound has good kinase inhibition activity and can be used for preventing and/or treating diseases mediated by abnormal expression of TAM family kinase and/or a ligand thereof. The compound can target CSF1R kinase and can be used for preventing and/or treating diseases mediated by abnormal expression of a TAM family kinase receptor and/or a CSF1R kinase receptor and/or ligands thereof.

Pyridone Derivatives

Novel compounds or salts thereof, or crystals thereof, which inhibit Axl and are useful for treating diseases caused by Axl hyperfunction, diseases associated with Axl hyperfunction and/or diseases accompanied by Axl hyperfunction are provided. Pyridone derivatives represented by the formula (1) having various substituents or salts thereof, or crystals thereof (where R1, R2, R3, R5, R6, A, W, X and n in the formula (1) are as defined in the specification, respectively) are provided.