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1398708-33-2

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1398708-33-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1398708-33-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,9,8,7,0 and 8 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1398708-33:
(9*1)+(8*3)+(7*9)+(6*8)+(5*7)+(4*0)+(3*8)+(2*3)+(1*3)=212
212 % 10 = 2
So 1398708-33-2 is a valid CAS Registry Number.

1398708-33-2Downstream Products

1398708-33-2Relevant articles and documents

AZETIDINE DERIVATIVE AND ANTIDEPRESSANT COMPOSITION INCLUDING THE SAME

-

, (2014/06/25)

The present invention relates to an azetidine derivative or a pharmaceutically acceptable salt thereof, and an antidepressant agent or a composition for the prevention or treatment of psychiatric disorders including the same. The azetidine derivative is useful as a triple reuptake inhibitor capable of inhibiting reuptake of the neurotransmitters, dopamine, serotonin, and norepinephrine at the same time.

Exploration of novel 3-substituted azetidine derivatives as triple reuptake inhibitors

Han, Younghue,Han, Minsoo,Shin, Dongyun,Song, Chiman,Hahn, Hoh-Gyu

, p. 8188 - 8192 (2012/11/07)

Novel azetidines based on the 3-aryl-3-oxypropylamine scaffold were designed, synthesized, and evaluated as TRIs. Reduction of 1 followed by Swern oxidation and then Grignard reaction gave 3. The alkylation of 3 provided the corresponding azetidine derivatives 6, of which the two most promising, 6bd and 6be, were selected from 86 prepared analogues based on their biological profiles. Compound 6be showed activity in vivo in FST at 10 mg/kg IV or 20-40 mg/kg PO.

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