1398805-45-2Relevant academic research and scientific papers
Two-fold modification of the phenyl substituent in phenylphosphonic acid monoester monoamides
Stankevic, Marek,Bazan, Jolanta
, p. 8244 - 8256 (2012)
Phenylphosphonic acid ethyl ester N,N-diethylamide was subjected to a double modification of its phenyl substituent through directed ortho-metalation followed by dearomatization of the aryl substituent under Birch reduction conditions. Application of the same methodology to a diastereomerically pure phenylphosphonic acid monoester monoamide led to the formation of P-stereogenic cyclohexadienyl-phosphonic acid derivatives. The method offers a simple and efficient modification of phenyl substituent in organophosphorus compounds.
