1398940-16-3

Upstream product

• 88-75-5 2-hydroxynitrobenzene 
• 112-60-7 Tetraethylene glycol 
• 72806-66-7 2-(2-methoxyethoxy)phenylamine 
• 1398940-15-2 2,2'-((2-(2-methoxyethoxy)phenyl)azanediyl)diethanol 
• 129264-07-9 1,17-ditosyl-3,6,9,12,15-pentaoxaheptadecane 
• 62819-95-8 1-(2-methoxyethoxy)-2-nitro-benzene 

Downstream Products

• 1398940-17-4 N-(4-nitro-2-methoxyethoxyphenyl)aza-[18]crown-6 ether 
• 1398940-18-5 N-(4-amino-2-methoxyethoxyphenyl)aza-[18]crown-6 ether 
• 1398940-03-8 7-(diethylamino)-3-{1-[3-(2-methoxyethoxy)-4-(1,4,7,10,13-pentaoxa-16-azacyclooctadecan-16-yl)phenyl]-1H-1,2,3-triazol-4-yl}-2H-chromen-2-one 
• 1398940-13-0 N-(4-azido-2-methoxyethoxyphenyl)aza-[18]crown-6 ether 

Relevant academic research and scientific papers

Potassium ion fluorescent probe as well as preparation method and application thereof (by machine translation)

The invention relates to a potassium ion fluorescent probe and a preparation method and application thereof (I). The potassium ion fluorescent probe provided by the invention NK1 has the advantages of short synthesis steps and simple structure, wherein, the synthesis steps of the potassium ion fluorescent probe are K ACLE as follows. + To the identification unit BODIPY, the derivative serves TPP as a fluorophore and as a mitochondria targeting group and is matched, so that the potassium ion fluorescent probe has high selectivity and sensitivity in the process of recognizing potassium ions. The NK1 human cervical cancer (HeLa) cell is small in toxic and side effects, high in biocompatibility and capable of targeting mitochondria. In addition, the method provided by the NK1 invention can qualitatively monitor the intracellular or outflow of potassium ions in the cell mitochondria. (by machine translation)

A highly K+-selective phenylaza-[18]crown-6-lariat-ether-based fluoroionophore and its application in the sensing of K+ ions with an optical sensor film and in cells

Herein, we report the synthesis of two phenylaza-[18]crown-6 lariat ethers with a coumarin fluorophore (1 and 2) and we reveal that compound 1 is an excellent probe for K+ ions under simulated physiological conditions. The presence of a 2-methoxyethoxy lariat group at the ortho position of the anilino moiety is crucial to the substantially increased stability of compounds 1 and 2 over their lariat-free phenylaza-[18]crown-6 ether analogues. Probe 1 shows a high K+/Na+ selectivity and a 2.5-fold fluorescence enhancement was observed in the presence of 100mM K+ ions. A fluorescent membrane sensor, which was prepared by incorporating probe 1 into a hydrogel, showed a fully reversible response, a response time of 150s, and a signal change of 7.8 % per 1mM K+ within the range 1-10mM K+. The membrane was easily fabricated (only a single sensing layer on a solid polyester support), yet no leaching was observed. Moreover, compound 1 rapidly permeated into cells, was cytocompatible, and was suitable for the fluorescent imaging of K+ ions on both the extracellular and intracellular levels. Copyright

Π (PI)-CONJUGATED FLUOROIONOPHORES AND METHOD FOR DETERMINING AN ALKALI ION

The present invention relates to π-conjugated fluoroionophores, methods for their preparation, and their use and a method for determining an alkali ion. Fluoroionophoric compounds of the general formula I are described Ionophore – π-Linker - Fluorophore (