13990-88-0Relevant academic research and scientific papers
Selective carboxylation of substituted phenols with engineered Escherichia coli whole-cells
Peng, Chang,Liu, Yuxue,Guo, Xiaojia,Liu, Wujun,Li, Qing,Zhao, Zongbao K.
, p. 3810 - 3815 (2018/09/21)
Selective carboxylation of substituted phenols is realized in the presence of bicarbonate under ambient pressure by engineered Escherichia coli whole-cells expressing various hydroxybenzoate decarboxylases, leading to their corresponding ortho-hydroxybenzoates. This process may be further developed as an efficient route to upgrade lignin-derived phenolic compounds as valuable building blocks.
Two-chamber hydrogen generation and application: Access to pressurized deuterium gas
Modvig, Amalie,Andersen, Thomas L.,Taaning, Rolf H.,Lindhardt, Anders T.,Skrydstrup, Troels
, p. 5861 - 5868 (2014/07/08)
Hydrogen and deuterium gas were produced and directly applied in a two-chamber system. These gaseous reagents were generated by the simple reaction of metallic zinc with HCl in water for H2 and DCl in deuterated water for D2. The setup proved efficient in classical Pd-catalyzed reductions of ketones, alkynes, alkenes, etc. in near-quantitative yields. The method was extended to the synthesis and isotope labeling of quinoline and 1,2,3,4-tetrahydroquinoline derivatives. Finally, CX-546 and Olaparib underwent efficient Ir-catalyzed hydrogen isotope exchange reactions.
