139914-48-0Relevant academic research and scientific papers
5-MEMBERED HETEROARYLAMINOSULFONAMIDES FOR TREATING CONDITIONS MEDIATED BY DEFICIENT CFTR ACTIVITY
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, (2021/05/21)
The invention relates to heteroaryl compounds, pharmaceutically acceptable salts thereof, and pharmaceutical preparations thereof. Also described herein are compositions and the use of such compounds in methods of treating diseases and conditions mediated by deficient CFTR activity, in particular cystic fibrosis.
An Enantioselective Approach to 4-O-Protected-2-cyclopentene-l,4-diol Derivatives via a Rhodium-Catalyzed Redox-Isomerization Reaction
Ren, Kai,Zhao, Mengmeng,Hu, Bei,Lu, Bin,Xie, Xiaomin,Ratovelomanana-Vidal, Virginie,Zhang, Zhaoguo
, p. 12572 - 12579 (2016/01/09)
Kinetic resolution of a series of cyclopentene-1,4-diol derivatives has been successfully achieved with enantiomeric excess up to 99.4% and a kf/ks ratio of 55 by a rhodium-catalyzed redox-isomerization reaction in a noncoordinating solvent.
NEW INDANYLOXYDIHYDROBENZOFURANYLACETIC ACIDS
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Paragraph 0713, (2013/10/07)
The present invention relates to compounds of general formula I, wherein the groups R1, R2 and m are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.
NEW INDANYLOXYDIHYDROBENZOFURANYLACETIC ACID DERIVATIVES AND THEIR USE AS GPR40 RECEPTOR AGONISTS
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Page/Page column 151, (2013/10/21)
The present invention relates to compounds of general formula I, (I), wherein the groups R1, R2 and m are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.
PTERIDINONES AS INHIBITORS OF POLO - LIKE KINASE
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, (2011/07/09)
The present invention provides compounds having a structure according to Formula (I) or a salt or solvate thereof, wherein ring A, X, R1, R2, R3, R4, R5 and R6, are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.
Application of high pressure induced by water-freezing to the Michael reaction of alcohols with α,β-enones
Hayashi, Yujiro,Nishimura, Koichi
, p. 296 - 297 (2007/10/03)
High pressure (about 200MPa), which was realized by freezing water in a sealed autoclave, has been successfully applied to a high-yield Michael reaction of alcohols and α,β-unsaturated ketones in the presence of a catalytic amount of DMAP and LiClO4. Only a moderate yield was obtained under atmospheric pressure.
Cyclic oxonium ylides: Building blocks for iterative synthesis of polycyclic ethers
Marms?ter, Fredrik P,Vanecko, John A,West
, p. 2027 - 2040 (2007/10/03)
A series of diazoketones bearing remote benzyl or allyl ethers was subjected to a variety of conditions for catalytic diazodecomposition and cyclic oxonium ylide formation as a possible method for polycyclic ether synthesis. Allyl ethers 19, 25 and 29 und
Profound Catalyst Effects in the Generation and Reactivity of Carbenoid-Derived Cyclic Ylides
West, F. G.,Naidu, B. N.,Tester, Richland W.
, p. 6892 - 6894 (2007/10/02)
In contrast to results with Rh2(OAc)4, good yields of ylide-derived -shift (or in some cases -shift) products were obtained upon treatment of amino diazo ketone substrates 3b,c and alkoxy diazo ketone substrates 5b,c with soluble Cu(II) catalyst
