139936-55-3

Upstream product

• 39828-43-8 6-hydroxy-6-(2-oxo-2,3-dihydro-1H-imidazol-4-yl)-hexanoic acid ethyl ester 
• 39215-48-0 ethyl 9-oxo-7,8-didehydrodethiobiotin 
• 139936-52-0 6-(1,3-Diacetyl-5-formyl-2-oxo-2,3-dihydro-1H-imidazol-4-yl)-hexanoic acid ethyl ester 
• 39828-42-7 4-(5-ethoxycarbonyl-1-oxovaleryl)imidazolin-2-one 
• 1071-71-2 ethyl 6-chloro-6-oxohexanoate 
• 139936-53-1 ethyl (+/-)-N,N'-diacetyl-9-hydroxydethiobiotin 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 139936-57-5 (+/-)-9-mercaptodethiobiotin 

Relevant academic research and scientific papers

Synthesis and Biological Activity of 9-Mercaptodethiobiotin - a Putative Biotin Precursor in Escherichia coli

A total synthesis of (+/-)-9-mercaptodethiobiotin 3 via the aldehyde 9 is described.Compound (+/-)-3 does not function as a biotin replacement factor for an E. coli mutant (SA291) lacking the entire biotin synthesis operon (bioABFCD-) but supports growth of an E. coli bioA mutant.Compound (+/-)-3 also supports growth of transformed cells of SA291 carrying a plasmid encoding the E. coli biotin synthase (bioB) gene indicating that the compound may be able to substitute for dethiobiotin 2 as a substrate for biotin synthase.