
Journal of the Chemical Society. Perkin transactions I p. 255 - 258 (1992)
Update date:2022-08-03
Topics:
Baxter, Robert L.
Camp, Dominic J.
Coutts, Andrew
Shaw, Nicholas
A total synthesis of (+/-)-9-mercaptodethiobiotin 3 via the aldehyde 9 is described.Compound (+/-)-3 does not function as a biotin replacement factor for an E. coli mutant (SA291) lacking the entire biotin synthesis operon (bioABFCD-) but supports growth of an E. coli bioA mutant.Compound (+/-)-3 also supports growth of transformed cells of SA291 carrying a plasmid encoding the E. coli biotin synthase (bioB) gene indicating that the compound may be able to substitute for dethiobiotin 2 as a substrate for biotin synthase.
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