139962-94-0

Upstream product

• 7507-86-0 2-bromo-5-methoxy-benzaldehyde 
• 122-51-0 orthoformic acid triethyl ester 

Downstream Products

• 1609472-08-3 1-(2-(diethoxymethyl)-4-methoxyphenyl)-1-(4-methoxyphenyl)ethanol 
• 1609472-27-6 C₁₉H₂₂O₄ 
• 1609471-99-9 8-methoxy-5-methyl-11-phenyl-5H-benzo[b]carbazole 
• 1609471-98-8 (2-(diethoxymethyl)-4-methoxyphenyl)(thiophen-2-yl)methanol 
• 1609471-97-7 (2-(diethoxymethyl)-4-methoxyphenyl)(2,3,4-trimethoxyphenyl)methanol 
• 1609471-95-5 (4-chlorophenyl)(2-(diethoxymethyl)-4-methoxyphenyl)methanol 
• 1609471-94-4 (2-(diethoxymethyl)-4-methoxyphenyl)(phenyl)methanol 
• 1408058-86-5 C₂₁H₃₁N₂O⁽¹⁺⁾*Cl^(1-) 
• 1408058-83-2 C₂₀H₃₂N₂O 
• 1408058-80-9 C₁₄H₁₉NO₂ 

Relevant academic research and scientific papers

Copper-Catalyzed One-Pot Cascade Cyclization for the Synthesis of Isoindolo[2,1-a]quinoxalines

A copper-catalyzed one-pot cascade cyclization of 2-(1-(acetyloxy)propargyl)benzaldehydes with o-phenylenediamines for an access to substituted isoindolo[2,1-a]quinoxalines has been developed. The reaction features readily available starting materials, simple operational procedure, and broad substrate scopes. Under optimal conditions, various isoindolo[2,1-a]quinoxalines were afforded in 41–88% yields. (Figure presented.).

Construction of complex bisether-bridged medium-sized cyclic compounds from o-(1-(acyloxy)propargyl)benzaldehydes under base and acid catalysis

We report herein our serendipitous discovery of the rapid and straightforward accesses to unprecedented diverse complex molecular structures from readily available starting materials. Catalyzed by 1,8-diazabicyclo[5.4.0]undec-7-ene under mild conditions, o-(1-(acyloxy)propargyl)benzaldehydes 1 underwent efficient and selective dimerization reactions to produce novel complex bisether-bridged tricyclic products 3 and 4. The reactions proceeded most probably through dimerizations between 3-methylene-3H-isochromene intermediate and its zwitterionic resonance structures which were generated from a concerted 6-πelectrocyclic ring closure reaction from the initially formed (2-formylphenyl)allene intermediates derived directly from o-(1-(acyloxy)propargyl)benzaldehydes. Treatment of the resulting product simply with NaOEt in ethanol and aqueous HCl, respectively, enabled further development of complex molecular diversities.

Asymmetric Synthesis of Multifunctionalized 2,3-Benzodiazepines by a One-Pot N-heterocyclic Carbene/Chiral Palladium Sequential Catalysis

We report the first example of the construction of chiral 2,3-benzodiazepine compounds which are of biologic and pharmaceutical relevance by asymmetric catalysis. Catalyzed by a thiazolium-derived carbene and a palladium-chiral bidentate phosphine complex

Total synthesis of plagiochins C, and D, macrocyclic bis(bibenzyl) constituents of plagiochila acantophylla

Plagiochins C (3) and D (4) were synthesized by convergent schemes. Rings C and B were joined by Ullman ether synthesis, the aryl-aryl bond between rings A and D was formed by Pd(0)-catalysed coupling of an arylboronic acid (ring D) and a bromobenzoic ester (ring A). Rings C and D were linked by the Wittig reaction, while final ring closure was effected by tetraphenylethene assisted Wurtz reaction.