13999-72-9Relevant academic research and scientific papers
A new synthesis of versatile indolyl-3-carbonylnitriles
Veale, Clinton G.L.
, p. 5287 - 5290 (2015/08/26)
Abstract Indolyl-3-carbonylnitriles are compounds with demonstrated utility as intermediates in organic chemistry. However, their synthesis remains a challenge, requiring the use of toxic sources of cyanide, and often proceeding in low yields. Accordingly, presented here is a new synthesis of these versatile reactants, via dehydration of easily accessible α-oxoacetamides in generally high yields under simple reaction conditions.
Solvatochromic fluorescent 2-substituted 3-ethynyl quinoxalines: Four-component synthesis, photophysical properties, and electronic structure
Gers, Charlotte F.,Nordmann, Jan,Kumru, Ceyda,Frank, Walter,Müller, Thomas J. J.
, p. 3296 - 3310 (2014/05/06)
2-Substituted 3-ethynylquinoxalines can be rapidly synthesized in generally excellent yields by a consecutive four-component synthesis starting from electron-rich π-nucleophiles, oxalyl chloride, terminal alkynes, and 1,2-diaminoarenes. The title compound
Three-component synthesis of ynediones by a glyoxylation/ Stephens-Castro coupling sequence
Merkul, Eugen,Dohe, Janis,Gers, Charlotte,Rominger, Frank,Mueller, Thomas J. J.
supporting information; experimental part, p. 2966 - 2969 (2011/05/04)
(Chemical Equation Presented) One step back, two steps forward! Starting from diverse heterocycles, the title reaction furnishes ynediones under very mild conditions in a direct and preparatively simple one-pot process. The key to avoiding decarbonylation
New three-component glyoxylation-decarbonylative stille coupling sequence to Acyl heterocycles under mild conditions
Tasch, Boris O. A.,Merkul, Eugen,Frank, Walter,Mueller, Thomas J.J.
experimental part, p. 2139 - 2146 (2010/09/04)
A consecutive sequence of glyoxylation of 1-methyl-1H-indole, 1-(4-methoxybenzyl)-1H-pyrrolo[2,3-b]pyridine or N-substituted pyrroles with oxalyl chloride and subsequent decarbonylative Stille coupling under very mild, Lewis acid free conditions using all reactants in equimolar quantities is reported. As an illustration, this glyoxylation-decarbonylative coupling sequence was elaborated into a consecutive, four-component synthesis of 1-methyl-3-(1-methyl-4,5-dihydro-1H-pyrazol-3-yl)-1H-indole. Georg Thieme Verlag Stuttgart - New York.
Consecutive three-component synthesis of ynones by decarbonylative sonogashira coupling
Merkul, Eugen,Oeser, Thomas,Mueller, Thomas J.J.
supporting information; experimental part, p. 5006 - 5011 (2009/12/07)
A study was conducted to demonstrate consecutive three-component synthesis of ynones by decarbonylative Sonogashira coupling. Sonogashira coupling started from electron-rich heterocycles and oxalyl chloride as a source of the CO building block via interme
