140-40-9 Usage
Uses
Used in Pharmaceutical Industry:
2-ACETAMIDO-5-NITROTHIAZOLE is used as an anti-inflammatory agent for its ability to reduce inflammation and alleviate pain. It is also used as a glucocorticoid, which helps to suppress the immune system and is beneficial in treating various inflammatory and autoimmune conditions.
Used in Chemotherapy:
2-ACETAMIDO-5-NITROTHIAZOLE is used as a chemotherapy drug, specifically for its role in the treatment of cancer. It works by inhibiting the growth and proliferation of cancer cells, making it a valuable component in the fight against the disease.
Used in Antibacterial Applications:
As a protistocide drug, 2-ACETAMIDO-5-NITROTHIAZOLE is used for its antibacterial activity, helping to combat bacterial infections and promote overall health.
Used in Research and Development:
Due to its unique chemical properties and potential applications, 2-ACETAMIDO-5-NITROTHIAZOLE is also used in research and development for the discovery of new drugs and therapies, particularly in the fields of oncology and infectious diseases.
Safety Profile
Poison by ingestion. Mutation data reported. When heated to decomposition it emits toxic fumes of SO, and NOx,.
Purification Methods
Recrystallise acinitrazole from EtOH or AcOH. [Hurd & Wehrmeister J Am Chem Soc 71 4007 1949, Beilstein 27 III/IV 4676.]
Check Digit Verification of cas no
The CAS Registry Mumber 140-40-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,4 and 0 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 140-40:
(5*1)+(4*4)+(3*0)+(2*4)+(1*0)=29
29 % 10 = 9
So 140-40-9 is a valid CAS Registry Number.
InChI:InChI=1/C5H5N3O3S/c1-3(9)7-5-6-2-4(12-5)8(10)11/h2H,1H3,(H,6,7,9)
140-40-9Relevant academic research and scientific papers
2-Acylamino-5-nitro-1,3-thiazoles: Preparation and in vitro bioevaluation against four neglected protozoan parasites
Nava-Zuazo, Carlos,Chávez-Silva, Fabiola,Moo-Puc, Rosa,Chan-Bacab, Manuel Jesús,Ortega-Morales, Benjamín Otto,Moreno-Díaz, Hermenegilda,Díaz-Couti?o, Daniel,Hernández-Nú?ez, Emanuel,Navarrete-Vázquez, Gabriel
, p. 1626 - 1633 (2014/03/21)
The 2-acylamino-5-nitro-1,3-thiazole derivatives (1-14) were prepared using a one step reaction. All compounds were tested in vitro against four neglected protozoan parasites (Giardia intestinalis, Trichomonas vaginalis, Leishmania amazonensis and Trypanosoma cruzi). Acetamide (9), valeroylamide (10), benzamide (12), methylcarbamate (13) and ethyloxamate (14) derivatives were the most active compounds against G. intestinalis and T. vaginalis, showing nanomolar inhibition. Compound 13 (IC50 = 10 nM), was 536-times more active than metronidazole, and 121-fold more effective than nitazoxanide against G. intestinalis. Compound 14 was 29-times more active than metronidazole and 6.5-fold more potent than nitazoxanide against T. vaginalis. Ureic derivatives 2, 3 and 5 showed moderate activity against L. amazonensis. None of them were active against T. cruzi. Ligand efficiency indexes analysis revealed higher intrinsic quality of the most active 2-acylamino derivatives than nitazoxanide and metronidazole. In silico toxicity profile was also computed for the most active compounds. A very low in vitro mammalian cytotoxicity was obtained for 13 and 14, showing selectivity indexes (SI) of 246,300 and 141,500, respectively. Nitazoxanide showed an excellent leishmanicidal and trypanocidal effect, repurposing this drug as potential new antikinetoplastid parasite compound.
