14006-54-3

Basic information

• Product Name: 3-CHLORO-1-BENZOTHIOPHENE-2-CARBALDEHYDE
• Synonyms: 3-chloro-1-benzothiophene-2-carbaldehyde(SALTDATA: FREE);3-Chloro-2-benzothiophenecarboxaldehyde;3-Chlorobenzo[b]thiophene-2-carboxaldehyde;3-chlorobenzothiophene-2-carbaldehyde;Benzo[b]thiophene-2-carboxaldehyde, 3-chloro-
• CAS NO: 14006-54-3
• Molecular Formula: C₉H₅ClOS
• Molecular Weight: 196.6566
• Product Categories: Heterocycles
• Mol File: 14006-54-3.mol
• Article Data: 16

Chemical Properties

• Melting Point: 112-113℃ (hexane )
• Boiling Point: 331.1°Cat760mmHg
• Flash Point: 154°C
• Appearance: /
• Density: 1.439g/cm³
• Vapor Pressure: 0.00016mmHg at 25°C
• Refractive Index: 1.722
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-CHLORO-1-BENZOTHIOPHENE-2-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-1-BENZOTHIOPHENE-2-CARBALDEHYDE(14006-54-3)
• EPA Substance Registry System: 3-CHLORO-1-BENZOTHIOPHENE-2-CARBALDEHYDE(14006-54-3)

Safety Data

• Statements: 25-36-43
• Safety Statements: 26-36/37-45
• RIDADR: UN 2811 6.1 / PGIII
• Hazardous Substances Data: 14006-54-3(Hazardous Substances Data)

Usage

General Description

3-Chloro-1-benzothiophene-2-carbaldehyde is a chemical compound with the molecular formula C10H7ClOS. It is a yellow to orange solid and is primarily used as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and organic compounds. This chemical is known for its strong odor and is classified as a potentially hazardous substance. It is commonly used in research and development laboratories for its role as a building block in the production of complex organic molecules. Additionally, it has applications in chemical reactions and processes that require the introduction of a carbonyl group into a molecule. Its unique chemical structure and reactivity make it a valuable tool in organic synthesis and medicinal chemistry.

InChI:InChI=1/C9H5ClOS/c10-9-6-3-1-2-4-7(6)12-8(9)5-11/h1-5H

Upstream product

• 136809-07-9 1-tert-butyl-4-phenyl-1-aza-1,3-butadiene 
• 2461-80-5 diphenacyl sulfide 
• 68-12-2 N,N-dimethyl-formamide 
• 2462-02-4 2-mercaptoacetophenone 
• 2461-75-8 benzoylmethyl disulfide 
• 17890-56-1 benzothiophene-2-methanol 
• 21211-07-4 3-chlorobenzo[b]thiophene-2-carboxylic acid methyl ester 
• 21211-22-3 3-chloro-1-benzothiophene-2-carboxylic acid 
• 135-13-7 (o-carboxyphenyl)thioacetic acid 
• 124168-55-4 (3-chloro-benzo[b]thiophen-2-yl)-methanol 
• 93-61-8 N-methyl-N-phenylformamide 

Downstream Products

• 96907-90-3 3-chloro-2-benzothiophene 
• 96907-91-4 3-chloro-2-benzothiophene 
• 19722-96-4 3-phenylbenzo(b)thiophene-2-carboxaldehyde 
• 59812-38-3 (3-chloro-1-benzothiophen-2-yl)(phenyl)methanone 
• 14006-55-4 3-chlorobenzo[b]thiophene-2-carbaldehyde oxime 
• 124168-55-4 (3-chloro-benzo[b]thiophen-2-yl)-methanol 
• 247-52-9 benzo<4,5>thieno<3,2-b>thiophene 
• 30126-05-7 thieno[3,2-b]-[1]benzothiophene-2-carboxylic acid 
• 100954-79-8 3-chloro-benzo[b]thiophene-2-carbaldehyde-phenylhydrazone 
• 124120-50-9 (3-chloro-benzo[b]thiophen-2-yl)-bis-(4-dimethylamino-phenyl)-methane 
• 272459-78-6 1-(3-phenylbenzo[b]thiophen-2-yl)ethan-1-one 

Relevant articles and documents

Polythienobenzothiophenes, a new family of electroactive polymers: Electrosynthesis, spectral characterization and modelling

New conducting polymers, including poly[thieno[3,2-b][1]benzothiophene] (poly-TBT) and poly [6-methoxythieno[3,2-b][1]benzothiophene] (poly-MeOTBT) were electrosynthesized by anodic oxidation of the corresponding monomers in 0.1 M LiClO4 acetonitrile solution. Poly-TBT and poly-MeOTBT electroactive films were formed on platinum electrodes and characterized spectroscopically. FT-IR studies show that both polymers present couplings occurring on the thiophene moiety and the phenyl ring, with a step-like structure. MALDI-TOF mass spectrometry indicates that poly-TBT and poly-MeOTBT films are mainly constituted of short-chain oligomers. The results of molecular orbital (MO) calculations performed on the basis of a radical-cation electropolymerization mechanism are in good agreement with our spectral data.

Efficient preparation method of 3-substitued-benzo five-membered heterocycle-2-carbonyl compound

The invention discloses an efficient compounding method of a 3-substitued-benzo five-membered heterocycle-2-carbonyl compound. According to the method, a 3-substitued-benzo five-membered heterocycle-2-alcohol compound is subjected to a halogenated oxidation reaction by a halogenating reagent to generate the corresponding 3-substitued-benzo five-membered heterocycle-2-carbonyl compound. The efficient compounding method has the advantages that raw materials are easy to get, reaction conditions are mild, and reaction selectively and yield are high.

Agents and methods for treating ischemic and other diseases

This invention relates to compounds that modulate TRPM7 protein activity and use of the same for treatment or prophylaxis of ischemia, cancer, pain or glaucoma.