14007-05-7

Basic information

• Product Name: piperazine hydrobromide
• Synonyms: piperazine hydrobromide
• CAS NO: 14007-05-7
• Molecular Formula: C4H11BrN2
• Molecular Weight: 167.04754
• EINECS: 237-811-6
• Mol File: 14007-05-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 707.1°Cat760mmHg
• Flash Point: 381.4°C
• Appearance: /
• Density: 1.92g/cm³
• Vapor Pressure: 4.05mmHg at 25°C
• CAS DataBase Reference: piperazine hydrobromide(CAS DataBase Reference)
• NIST Chemistry Reference: piperazine hydrobromide(14007-05-7)
• EPA Substance Registry System: piperazine hydrobromide(14007-05-7)

Safety Data

• Hazardous Substances Data: 14007-05-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C4H10N2.BrH/c1-2-6-4-3-5-1;/h5-6H,1-4H2;1H

Upstream product

• 110-85-0 piperazine 
• 724788-70-9 8-bromo-7-fluoro-2-methoxy-1,5-naphthyridine 
• 120952-09-2 2-bromo-N-ethylpyridinium tetraphenylborate 
• 79343-93-4 1-ethyl-2-bromo-pyridinium; bromide 
• 10035-10-6 hydrogen bromide 
• 5450-74-8 1,4-dimethyl-1,4-diazabicyclo[2.2.2]octane-1,4-diium dibromide 

Downstream Products

• 124953-47-5 4-(5-Methyl-3-phenyl-isoxazole-4-carbonyl)-piperazine-1-carbothioic acid (2-cyano-4,5-dimethoxy-phenyl)-amide 
• 124953-49-7 4-[3-(3-Bromo-isoxazol-5-yl)-propionyl]-piperazine-1-carbothioic acid (2-cyano-4,5-dimethoxy-phenyl)-amide 
• 124953-48-6 4-(5-Phenyl-isoxazole-3-carbonyl)-piperazine-1-carbothioic acid (2-cyano-4,5-dimethoxy-phenyl)-amide 
• 124953-46-4 4-(3-Phenyl-isoxazole-5-carbonyl)-piperazine-1-carbothioic acid (2-cyano-4,5-dimethoxy-phenyl)-amide 
• 124953-44-2 4-(3-Methoxy-isoxazole-5-carbonyl)-piperazine-1-carbothioic acid (2-cyano-4,5-dimethoxy-phenyl)-amide 
• 124953-42-0 4-(3-Bromo-isoxazole-5-carbonyl)-piperazine-1-carbothioic acid (2-cyano-4,5-dimethoxy-phenyl)-amide 
• 124953-43-1 4-(3-Chloro-isoxazole-5-carbonyl)-piperazine-1-carbothioic acid (2-cyano-4,5-dimethoxy-phenyl)-amide 

Relevant articles and documents

Efficient diffusion-controlled ligand exchange crystal growth of isostructural inorganic-organic halogenidorhodates(III): The missing hexaiodidorhodate(iii) anion

The monohydrates of piperazine-1,4-diium hexabromidorhodate(III) bromide and hexaiodidorhodate(III) iodide were obtained by a diffusion-controlled ligand exchange crystal growth method using a hydrochloric acid solution of rhodium(III) chloride trihydrate and piperazine, dissolved in hydrobromic and hydroiodic acid, respectively, separated by a layer of hydrohalic acid. Both inorganic-organic hybrids are defined by the general formula (C4H12N2)2[RhX6]X·H2O (X = Br, 1 or I, 2). They both crystallize in the orthorhombic Pnma space group, and they are isostructural with an isostructurality index above 95%. The cationic building blocks-piperazine-1,4-diium ions and the inorganic components-slightly distorted octahedral [RhX6]3- complexes, isolated X- anions and water of crystallization molecules are connected by related but different systems of interactions. The comparison of packing arrangements and interactions in the crystals of 1 and 2 with those in metal-free (C4H12N2)Br2·H2O, 3, and (C4H12N2)I2·I2, 4, clearly illustrates the occurrence and hierarchy of specific interactions: the bromide-containing structures are dominated by the O/N/C-H···X hydrogen bonds that are less pronounced or exchanged by the X···X halogen bonds in the corresponding iodide-containing structures. The structural features derived from the X-ray diffraction studies are confirmed by the solid-state IR and Raman spectroscopic results supported by the thermoanalytical analyses.

OXAZOLIDINONE ANTIBIOTICS

The invention relates to compounds of formula (I) wherein U, V, W, X, R1, R2, R3, R4, R5, R6, A, B, D, E, G, m and n are as defined in the description, to pharmaceutically acceptable salts of such compounds for use in the manufacture of a medicament for the prevention or treatment of a bacterial infection. Certain compounds of formula (I) are new and are also part of this invention.

EFFECT OF THE NATURE OF THE LEAVING GROUP IN REACTIONS OF 2-X-N-ETHYLPYRIDINIUM SALTS WITH AMINES IN ACETONITRILE

The rate-determining stage in the nucleophilic substitution reactions of 2-X-N-ethylpyridinium salts with piperidine in acetonitrile changes, depending on the nature of the leaving group X.In the case where X = Hlg the controlling stage is the formation of the C-N bond.When X = 4-NO2C6H4O3, 3,4-(NO2)2C6H3O, and 2,6-(NO2)2C6H3O, nucleophilic substitution at the carbon atom is controlled by cleavage of the C-X bond.Nucleophilic substitution at a carbon atom of the benzene ring predominates in the reaction of 2-(2,4-dinitrophenoxy)-N-ethylpyridinium salt with piperidine.