14007-64-8 Usage
Originator
Butetamat-dihydrogencitrat,Chemische Werke
Hommel GmbH
and Co.KG
Manufacturing Process
16.4 parts of alpha-phenylbutiric acid, 17.5 parts of beta-diethylaminoethylchloride hydrochloride and 35 parts of dry potassium
carbonate in 60 parts diisopropyl ether was stirred for 18 hours under reflux.
To the reaction mixture at 40°C was added 120 parts of the water. Organic
layer was washed with the water. The solvent was removed and the 2-
(diethylamino)ethyl-2-phenylbutyrate was distilled at 167-168°C/10 mm;
melting point of hydrochloride 167-169°C.In practice it is usually used as citrate.
Check Digit Verification of cas no
The CAS Registry Mumber 14007-64-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,0,0 and 7 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 14007-64:
(7*1)+(6*4)+(5*0)+(4*0)+(3*7)+(2*6)+(1*4)=68
68 % 10 = 8
So 14007-64-8 is a valid CAS Registry Number.
InChI:InChI=1/C16H25NO2/c1-4-15(14-10-8-7-9-11-14)16(18)19-13-12-17(5-2)6-3/h7-11,15H,4-6,12-13H2,1-3H3
14007-64-8Relevant articles and documents
Caesium fluoride-mediated hydrocarboxylation of alkenes and allenes: Scope and mechanistic insights
Gevorgyan, Ashot,Obst, Marc F.,Guttormsen, Yngve,Maseras, Feliu,Hopmann, Kathrin H.,Bayer, Annette
, p. 10072 - 10078 (2019/11/14)
A caesium fluoride-mediated hydrocarboxylation of olefins is disclosed that does not rely on precious transition metal catalysts and ligands. The reaction occurs at atmospheric pressures of CO2 in the presence of 9-BBN as a stoichiometric reductant. Stilbenes, β-substituted styrenes and allenes could be carboxylated in good yields. The developed methodology can be used for preparation of commercial drugs as well as for gram scale hydrocarboxylation. Computational studies indicate that the reaction occurs via formation of an organocaesium intermediate.