1400898-71-6

Basic information

• Product Name: 4-N-benzylcytosine 5-methylsulfonic acid sodium salt
• Synonyms: 4-N-benzylcytosine 5-methylsulfonic acid sodium salt
• CAS NO: 1400898-71-6
• Molecular Weight: 317.301
• Mol File: 1400898-71-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-N-benzylcytosine 5-methylsulfonic acid sodium salt(CAS DataBase Reference)
• NIST Chemistry Reference: 4-N-benzylcytosine 5-methylsulfonic acid sodium salt(1400898-71-6)
• EPA Substance Registry System: 4-N-benzylcytosine 5-methylsulfonic acid sodium salt(1400898-71-6)

Safety Data

• Hazardous Substances Data: 1400898-71-6(Hazardous Substances Data)

Upstream product

• 1333466-54-8 4-N-(benzyl-5-hydroxymethyl)cytosine 
• 5785-16-0 N⁴-benzylcytosine 
• 1346635-30-0 C₁₁H₉N₃O 
• 100-52-7 benzaldehyde 

Relevant articles and documents

New cytosine derivatives as inhibitors of DNA methylation

DNA cytosine methylation catalyzed by DNA methyltransferase 1 (DNMT1) is an epigenetic method of gene expression regulation and development. Changes in methylation pattern lead to carcinogenesis. Inhibition of DNMT1 activity could be a good strategy of safe and efficient epigenetic therapy. In this work, we present a novel group of cytosine analogs as inhibitors of DNA methylation. We show new methods of synthesis and their effect on in vitro reaction of DNA methylation. Almost all of analyzed compounds inhibit DNA methyltransferase activity in the competitive manner. Ki values for the most potent compound 4-N-furfuryl-5,6-dihydroazacytosines is 0.7 μM. These compounds cause also a decrease of 5-methylcytosine (m5C) level in DNA of mammalian HeLa and HEK293 cells.