1401073-62-8

Basic information

• Product Name: ethyl 2-(1H-indol-3-yl)-2-(p-tolylamino)acetate
• Synonyms: ethyl 2-(1H-indol-3-yl)-2-(p-tolylamino)acetate
• CAS NO: 1401073-62-8
• Molecular Weight: 308.38
• Mol File: 1401073-62-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: ethyl 2-(1H-indol-3-yl)-2-(p-tolylamino)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(1H-indol-3-yl)-2-(p-tolylamino)acetate(1401073-62-8)
• EPA Substance Registry System: ethyl 2-(1H-indol-3-yl)-2-(p-tolylamino)acetate(1401073-62-8)

Safety Data

• Hazardous Substances Data: 1401073-62-8(Hazardous Substances Data)

Upstream product

• 120-72-9 indole 
• 121641-60-9 ethyl 2-(4-methylphenylimino)acetate 
• 21911-68-2 ethyl 2-(p-tolylamino)acetate 

Relevant articles and documents

Preparation method of asymmetric gem-diaryl acetate compound

The invention relates to a preparation method of an asymmetric gem-diarylacetate compound, which comprises the following steps: (1) stirring and reacting a glycine derivative, a compound Ar and a catalyst aluminum trichloride in an organic solvent at 20-30 DEG C to obtain an N-aryl-[alpha]-aryl glycine derivative, wherein R is methyl or methoxyl; and (2) sequentially adding the N-aryl-[alpha]-arylglycine derivative obtained in the step (1), a compound Ar', a catalyst aluminum trichloride and a cocatalyst, and carrying out reflux reaction in an organic solvent at 70-90 DEG C to obtain the asymmetric gem-diarylacetate compound, the compound Ar and the compound Ar' are independently selected from aniline compounds, indole compounds or electron-rich arylether compounds, and the compound Ar' is different from the compound Ar. The reaction raw materials are low in price and easy to obtain, the reaction conditions are environment-friendly, the substrate application range is wide, pre-functionalization of the substrate is avoided, the operation is simple, and post-treatment is convenient.

Copper(I) chloride-catalyzed aerobic oxidative arylation of glycine ester and amide derivatives

A simple and efficient copper(I) chloridecatalyzed aerobic oxidative coupling of glycine derivatives (glycine esters, glycine amides and short peptides) with indoles has been developed. The reaction is performed in the absence of any other additives under mild conditions and only requires simple copper salts as a catalyst and oxygen as a cooxidant.

Merging visible-light photoredox and Lewis acid catalysis for the functionalization and arylation of glycine derivatives and peptides

A relay catalysis protocol for the functionalization of α-amino acids and dipeptides using a combination of visible-light photoredox and Lewis acid catalysis has been developed. The Royal Society of Chemistry.