1401404-45-2Relevant academic research and scientific papers
Unexpected cyclization of 2-(2-aminophenyl)indoles with nitroalkenes to furnish indolo[3,2-: C] quinolines
Aksenov, Alexander V.,Aksenov, Dmitrii A.,Griaznov, Georgii D.,Aksenov, Nicolai A.,Voskressensky, Leonid G.,Rubin, Michael
, p. 4325 - 4332 (2018)
The polyphosphoric acid-mediated reaction of 2-(2-aminophenyl)indenes with nitroalkenes was tested in the frame of synthetic studies towards CDK inhibitors with the paullone core. Unexpectedly, this reaction proceeded via a different mechanistic pathway affording derivatives of the natural alkaloid isocryptolepine. The scope of this unusual transformation was investigated and a mechanistic rationale explaining this outcome is offered.
Method for synthesizing indole[3,2-c]quinoline compound
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Paragraph 0099-0101, (2019/10/01)
The invention discloses a method for synthesizing an indole[3,2-c]quinoline compound, and belongs to the technical field of organic synthesis. A 2-alkynyl aniline compound 1 is subjected to a reactionby heating in a protic solvent in the presence of a rho
Tunable synthesis of indolo[3,2- c]quinolines or 3-(2-Aminophenyl)Quinolines via aerobic/anaerobic dimerization of 2-alkynylanilines
Jia, Ruixue,Li, Bin,Liang, Rong,Zhang, Xinying,Fan, Xuesen
supporting information, p. 4996 - 5001 (2019/07/03)
In this paper, an unprecedented selective synthesis of indolo[3,2-c]quinoline or 3-(2-aminophenyl)quinoline derivatives through Rh(III)-catalyzed stepwise dimerization of 2-alkynylanilines under aerobic or anaerobic conditions is presented. Notably, hexafluoroisopropanol is found to be a crucial solvent and promoter for the success of these reactions. In addition, the utility of the products thus obtained was showcased by their facile transformations into the pharmaceutically and photophysically significant naphthyridine derivatives.
An alternative one-pot gold-catalyzed approach to the assembly of 11H-indolo[3,2-c]quinolines
Abbiati, Giorgio,Arcadi, Antonio,Chiarini, Marco,Marinelli, Fabio,Pietropaolo, Emanuela,Rossi, Elisabetta
, p. 7801 - 7808 (2013/04/23)
A new one-pot approach was developed to construct the 11H-indolo[3,2-c] quinoline scaffold through a gold-catalysed reaction of 2-[(2-aminophenyl) ethynyl]phenylamine derivatives with aldehydes. The broad scope and the high regioselectivity of this new pr
