40754-13-0

Usage

Uses

Used in Chemical Synthesis:
2'-Aminoacetophenone phenylhydrazone is used as a reagent in chemical reactions for its ability to participate in various organic synthesis processes, contributing to the creation of a wide range of compounds.
Used in Research:
In the scientific community, 2'-aminoacetophenone phenylhydrazone is utilized as a building block in the synthesis of other organic compounds, facilitating the exploration of new chemical structures and their properties.
Used in Coordination Chemistry:
2'-Aminoacetophenone phenylhydrazone is used as a ligand to form coordination complexes with metal ions, which is crucial for studying metal-organic interactions and has implications in areas such as catalysis and materials science.
Used in Pharmaceutical Development:
Due to its potential biological and pharmacological activities, 2'-aminoacetophenone phenylhydrazone is employed in the development of new pharmaceuticals, where it may contribute to the discovery of novel therapeutic agents.
Used in Industrial Applications:
In industrial settings, 2'-aminoacetophenone phenylhydrazone is used in the production of various chemical products, leveraging its reactivity and ability to form stable complexes for specific applications.

Upstream product

• 551-93-9 2-aminoacetophenone 
• 100-63-0 phenylhydrazine 

Downstream Products

• 1401319-13-8 6-phenyl-5,6-dihydroindolo[1,2-c]quinazoline 
• 1252659-69-0 N-benzylidene-2-(1H-indol-2-yl)benzenamine 
• 1401404-43-0 6-(4-bromophenyl)-11H-indolo[3,2-c]quinoline 
• 1401404-44-1 6-(4-chlorophenyl)-11H-indolo[3,2-c]quinoline 
• 1239778-88-1 6-(4-chlorophenyl)indolo[1,2-c]quinazoline 
• 1448807-86-0 6-(4-nitrophenyl)-indolo[1,2-c]quinazoline 
• 1385821-07-7 6-(4-methoxyphenyl)-indolo[1,2-c]quinazoline 
• 1239778-99-4 6-(p-tolyl)indolo[1,2-c]quinazoline 
• 1401404-46-3 6-(4-methylphenyl)-11H-indolo[3,2-c]quinoline 

Relevant academic research and scientific papers

Selective C?H or N?H Imidoylative Annulation of 2-(2-Isocyanophenyl)-1H-indoles Leading to Diverse Indole-fused Scaffolds

2-(2-Isocyanophenyl)-1H-indoles, a class of functionalized isocyanides containing both aromatic C?H and indolo N?H functionalities, are first applied in selective imidoylative annulation reactions. Scaffolds of 6-aryl 11H-indolo[3,2-c]quinoline and 6-aryl

Unexpected cyclization of 2-(2-aminophenyl)indoles with nitroalkenes to furnish indolo[3,2-: C] quinolines

The polyphosphoric acid-mediated reaction of 2-(2-aminophenyl)indenes with nitroalkenes was tested in the frame of synthetic studies towards CDK inhibitors with the paullone core. Unexpectedly, this reaction proceeded via a different mechanistic pathway affording derivatives of the natural alkaloid isocryptolepine. The scope of this unusual transformation was investigated and a mechanistic rationale explaining this outcome is offered.

A nitroalkane-based approach to one-pot three-component synthesis of isocryptolepine and its analogs with potent anti-cancer activities

A second generation polyphosphoric acid-mediated one-pot three-component synthesis of indoloquinoline scaffold is developed. This improved version of the process involves electrophilically activated nitroalkanes for the installation of strategic C-C and C-N bonds and ring C assembly. This modification allows the elimination of unnecessary solvent change operations and all steps are carried out in a true, uninterrupted one-pot manner. A further improvement involves the possibility to install an ortho-amino group in situ. A synthetic application of this method is showcased by the concise synthesis of an isocryptolepine alkaloid and its synthetic analogs with potent anticancer activities.

Cation-Directed Enantioselective N-Functionalization of Pyrroles

A catalytic enantioselective N-functionalization of pyrroles has been developed. Imines formed in situ via condensation underwent cation-directed cyclization with complete N-regioselectivity. The cyclized products were obtained with enantiomeric ratios up

A new compound and an organic electronic device using the same

The present invention provides a new compound and an organic electronic device using the same. The compound according to the present invention may serve as hole injection, hole transporting, electron injection and transporting, and light emitting materials and the like in an organic electronic device comprising an organic light emitting device, and the organic electronic device according to the present invention shows excellent properties in terms of efficiency, driving voltage and service life.

Antimicrobial study of newly synthesized 6-substituted indolo[1,2-c]quinazolines

A new series of indolo[1,2-c]quinazoline derivatives were prepared in good yield through reaction of 2-(o-aminophenyl)indole with a variety of arylaldehydes. The structures of the newly synthesized compounds were confirmed by IR, 1H NMR, 1

New route to the synthesis of the isocryptolepine alkaloid and its related skeletons using a modified Pictet-Spengler reaction

A new route to the synthesis of the isocryptolepine alkaloid with antimalarial activity using a modified Pictet-Spengler reaction has been devised. The strategy was then used to generate libraries based on three structural variants of the alkaloid. Compounds based on these three variants in general were accessed in three steps through a modified Pictet-Spengler cyclization reaction as the key step. The C-2-, C-3-, or N-1-linked (aminoaryl)indoles (8, 12, 13) required for cyclization were obtained by treating the corresponding indoles with o-halonitrobenzene using either nucleophilic re-placement or Pd-based chemistry (Heck/Suzuki reaction) followed by reduction of the nitroaryl functionality. The substrates 8, 12, and 13 were then subjected to the Pictet-Spengler reaction to furnish polycyclic structures, indolo-quinolines 4 and 19 and indolo-quinoxalines 20 with three-point diversity in high yields and purities. One of the indolo-quinolines 4a after treatment with CH3I furnished the isocryptolepine alkaloid in excellent yield. Wiley-VCH Verlag GmbH & Co. KGaA, 2009.

Chemistry of Indoloquinazoline: An Approach to the Marine Alkaloid Hinckdentine A

The basic chemistry of indoloquinazoline (2) has been investigated for the first time.In addition, some attempts to elaborate 2 into the pentacyclic system of the marine alkaloid hinckdentine A (1A) are described.

2-Phenyl-indole derivatives and process for preparing the same

New stabilizers of polymers and co-polymers of vinyl chloride, the said stabilizers being 2-phenyl-indole derivatives corresponding to the formula: STR1 wherein R represents a phenyl radical, an amino group, optionally substituted by an acetyl or benzoyl