1401522-47-1

Basic information

• Product Name: (Z)-3-benzylidene-2-(4-hydroxybenzyl)isoindolin-1-one
• Synonyms: (Z)-3-benzylidene-2-(4-hydroxybenzyl)isoindolin-1-one
• CAS NO: 1401522-47-1
• Molecular Weight: 327.382
• Mol File: 1401522-47-1.mol

Chemical Properties

• CAS DataBase Reference: (Z)-3-benzylidene-2-(4-hydroxybenzyl)isoindolin-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-3-benzylidene-2-(4-hydroxybenzyl)isoindolin-1-one(1401522-47-1)
• EPA Substance Registry System: (Z)-3-benzylidene-2-(4-hydroxybenzyl)isoindolin-1-one(1401522-47-1)

Safety Data

• Hazardous Substances Data: 1401522-47-1(Hazardous Substances Data)

Upstream product

• 1086598-96-0 (Z)-3-benzylidene-2-(4-methoxybenzyl)-2,3-dihydro-isoindol-1-one 
• 5194-47-8 3-benzylidenephthalimidine 
• 36081-66-0 2'-bromo-2-phenylacetophenone 
• 1401522-29-9 C₂₄H₂₁NO₄ 
• 630393-48-5 2-(4-acetoxybenzyl) isoindoline-1,3-dione 
• 13005-36-2 potassium phenylacetate 

Relevant articles and documents

A Serendipitous One-Pot Cyanation/Hydrolysis/Enamide Formation: Direct Access to 3-Methyleneisoindolin-1-ones

A direct, one-pot conversion of 2’-haloacetophenones to 3-methyleneisoindolin-1-one scaffolds using CuCN as the sole reagent without the need for moisture-free or anaerobic conditions is reported. This serendipitously discovered transformation with a broa

Photodecarboxylative addition of carboxylates to phthalimides: A concise access to biologically active 3-(alkyl and aryl)methylene-1H-isoindolin-1-ones

A series of 3-(alkyl and aryl)methyleneisoindolin-1-one derivatives were synthesized in a simple two-step procedure using a recently established photodecarboxylative addition of carboxylates to phthalimides as the key-step. Subsequent acid-catalyzed dehydration and deprotection furnished the desired target compounds with high E-selectivity. The reaction sequence was applied to the synthesis of the known bioactive phenylethylene derivative, AKS-186. Different analogues, including heteroatom-containing isosteres were also synthesized using this approach.