5194-47-8Relevant academic research and scientific papers
A Serendipitous One-Pot Cyanation/Hydrolysis/Enamide Formation: Direct Access to 3-Methyleneisoindolin-1-ones
Banik, Trisha,Kaliappan, Krishna P.
supporting information, p. 628 - 633 (2020/12/09)
A direct, one-pot conversion of 2’-haloacetophenones to 3-methyleneisoindolin-1-one scaffolds using CuCN as the sole reagent without the need for moisture-free or anaerobic conditions is reported. This serendipitously discovered transformation with a broa
COMPOUND HAVING BET INHIBITORY ACTIVITY AND PREPARATION METHOD AND USE THEREFOR
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Paragraph 0260-0262, (2020/12/22)
The invention relates to the field of pharmaceutical chemistry. Specifically, the present invention relates to a series of BET (bromodomain and extra-terminal domain) inhibitors having a novel structure, particularly inhibitors targeting BRD4 (Bromodomain-containing protein 4), and a preparation method and use therefor. The structure thereof is shown in the following general formula (I). Said compounds or a stereoisomer, racemate, geometric isomer, tautomer, prodrug, hydrate, solvate, or crystal form thereof, or a pharmaceutically acceptable salt thereof, and the pharmaceutical compsosition thereof can be used for the treatment and/or prevention of related diseases mediated by bromodomain proteins.
A 3 - [...] indoline -1 - one derivatives of the synthesis method
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Paragraph 0038-0042, (2019/07/04)
The invention belongs to the medical and chemical intermediates and related chemical technical field, provides a 3 - [...] indoline - 1 - one derivatives of the synthetic method, in a simple and cheap and easy to obtain adjacent bromoxynil and phenylacety
DUAL SITE CATALYST FOR MILD, SELECTIVE NITRILE REDUCTION
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Paragraph 0058, (2016/06/09)
A ruthenium bis(pyrazolyl)borate scaffold that enables cooperative reduction reactivity in which boron and ruthenium centers work in concert to effect selective nitrile reduction is provided. The pre-catalyst compound [κ3-(1-pz)2HB(N═CHCH3)]Ru(cymene)? TfO? (pz=pyrazolyl) was synthesized using readily-available materials through a straightforward route, thus making it an appealing catalyst for a number of reactions.
A practical photochemically induced method for nin bond cleavage of n,n-disubstituted hydrazides
Lebrun, Stephane,Couture, Axel,Deniau, Eric,Grandclaudon, Pierre
experimental part, p. 2621 - 2624 (2010/01/07)
The development of an unprecedented methodology based upon direct photolysis of N,N-disubstituted hydrazides to secure N-N bond cleavage and to trigger the formation of NH-free lactams has been disclosed.
Incorporation of molecular nitrogen into organic compounds IV. Novel lactam synthesis by nitrogenation of enol lactones
Uozumi, Yasuhiro,Mori, Eiko,Mori, Miwako,Shibasaki, Masakatsu
, p. 93 - 102 (2007/10/02)
Enol lactones 7, which are readily prepared from o-haloacetophenone derivatives 15 by palladium-catalyzed carbonylation, react with the titanium-isocyanate complex (1) generated by fixation of CO2 with titanium-nitrogen complex to give the isoindolinone derivatives 8 in good yields.
CYCLIZATION OF VICINAL ACETYLENIC DERIVATIVES OF PYRAZOLECARBONAMIDES AND BENZAMIDES
Vasilevskii, S. F.,Shvartsberg, M. S.
, p. 1901 - 1905 (2007/10/02)
Vicinal acetylenic derivatives of pyrazolecarbonamides and benzamides cyclize in alcoholic solution in the presence of KOH with closure of the six- or five-membered lactam ring.The formation of γ-lactam (from o-phenylethynylbenzamide) has been noted for t
Indane-1,3-dione, Phthalimidine and Phthalide Derivatives as Alkylating Agents
Barili, Pier Luigi,Scartoni, Valerio
, p. 1199 - 1202 (2007/10/02)
The title compounds gave carbocations in acid media.The electrophilic aromatic substitution of those carbocations was studied.
