1401549-17-4

Basic information

• Product Name: [D₁]-acetophenone
• Synonyms: [D₁]-acetophenone
• CAS NO: 1401549-17-4
• Molecular Weight: 136.158
• Mol File: 1401549-17-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: [D₁]-acetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: [D₁]-acetophenone(1401549-17-4)
• EPA Substance Registry System: [D₁]-acetophenone(1401549-17-4)

Safety Data

• Hazardous Substances Data: 1401549-17-4(Hazardous Substances Data)

Upstream product

• 2142-69-0 2-bromophenyl methyl ketone 
• 50777-64-5 2-(2-bromophenyl)-2-methyl-1,3-dioxolane 
• 613-91-2 acetophenone oxime 

Relevant articles and documents

Easy Access to 1-Amino and 1-Carbon Substituted Isoquinolines via Cobalt-Catalyzed C - H/N - O Bond Activation

A green atom-economical method for the synthesis of highly functionalized 1-amino and 1-carbon substituted isoquinolines from the reaction of N′-hydroxybenzimidamides and aryl ketoximes, respectively, with alkynes via pentamethylcyclopentadienylcobalt(III)-catalyzed C - H/N - O bond activation is described. The external oxidant-free annulation reaction uses the =NOH moiety in N′-hydroxybenzimidamides or N-aromatic ketone oximes as the directing group and internal oxidant. This first row transition metal-catalyzed annulation serves as an efficient alternative for the synthesis of isoquinolines, as water is the only by-product and expensive noble metals such as rhodium(III), iridium(III), palladium(II), and ruthenium(II) are not required. The reaction proceeds via C - H activation, alkyne insertion, reductive elimination, and N - O activation.