1401616-00-9Relevant academic research and scientific papers
Visible-Light-Mediated Direct Decarboxylative Acylation of Electron-Deficient Heteroarenes Using α-Ketoacids
Manna, Sabyasachi,Prabhu, Kandikere Ramaiah
, (2019)
Acylation of electron-deficient heteroaromatic compounds has been developed using visible light. α-Ketoacids have been used as an efficient source of acyl radicals under photoredox conditions. The in situ generated acyl radicals from α-ketoacids have been coupled to a wide variety of electron-deficient heteroaromatic compounds in a Minisci type reaction. This method would be attractive to access biologically attractive molecules.
Acyl Radicals from α-Keto Acids: Metal-Free Visible-Light-Promoted Acylation of Heterocycles
Zhu, Hu-Lin,Zeng, Fan-Lin,Chen, Xiao-Lan,Sun, Kai,Li, Hao-Cong,Yuan, Xiao-Ya,Qu, Ling-Bo,Yu, Bing
supporting information, p. 2976 - 2980 (2021/05/05)
A general and metal-free visible-light-induced decarboxylative arylation procedure at room temperature was described for the construction of acylated heterocyclic derivatives, such as benzimidazo/indolo[2,1-a]isoquinolin-6(5H)-ones, aroylazaspiro[4.5]trie
I2-Promoted Povarov-Type Reaction Using 1,4-Dithane-2,5-diol as an Ethylene Surrogate: Formal [4 + 2] Synthesis of Quinolines
Wu, Xia,Geng, Xiao,Zhao, Peng,Zhang, Jingjing,Gong, Xingxing,Wu, Yan-Dong,Wu, An-Xin
supporting information, p. 1550 - 1553 (2017/04/13)
A highly efficient I2-promoted formal [4 + 2] cycloaddition has been developed for the synthesis of 2-acylquinolines from methyl ketones and arylamines using 1,4-dithane-2,5-diol as an ethylene surrogate. Moreover, the investigation of the mechanism suggested that this reaction occurred via an iodination/Kornblum oxidation/Povarov/aromatization sequence. It is noteworthy that the arylamine substrate also played an important role in promoting the reaction.
Transition-Metal-Free Acylation of Quinolines and Isoquinolines with Arylmethanols via Oxidative Cross-Dehydrogenative Coupling Reactions
Adib, Mehdi,Pashazadeh, Rahim,Rajai-Daryasarei, Saideh,Kabiri, Roya,Gohari, Seyed Jamal Addin
supporting information, p. 2241 - 2245 (2016/10/11)
An efficient acylation of quinolines and isoquinolines is described by use of arylmethanols as the acylating agents through a C-C bond formation via an oxidative cross-dehydrogenative coupling (CDC) strategy. This C-aroylation reaction was carried out by use of K2S2O8 as oxidant and methyltrioctylammonium chloride (Aliquat 336) as a transfer agent in MeCN at 80 °C under transition-metal-free conditions.
Regiospecific benzoylation of electron-deficient n -heterocycles with methylbenzenes via a minisci-type reaction
Ali, Wajid,Behera, Ahalya,Guin, Srimanta,Patel, Bhisma K.
, p. 5625 - 5632 (2015/06/16)
A regioselective cross-dehydrogenative coupling between electron-deficient N-heterocycles (isoquinoline, quinolines, and quinoxalines) and methylbenzenes leading to regiospecific C-aroylation has been accomplished using AlCl3 as the catalyst in
A general access to 1,1-cyclopropane aminoketones and their conversion into 2-benzoyl quinolines
Mao, Zhenjun,Qu, Haijun,Zhao, Yanyan,Lin, Xufeng
supporting information, p. 9927 - 9929 (2012/11/06)
1,1-Cyclopropane aminoketones were efficiently synthesized in high yields by the tandem reaction of α-amino aryl ketones with vinyl sulfonium salts using DBU as the base in CH2Cl2. This methodology was utilized to synthesize 2-benzoyl quinolines. The Royal Society of Chemistry 2012.
