1401665-01-7

Upstream product

• 142352-04-3 C₁₅H₁₅ClN₂ 
• 118-92-3 anthranilic acid 
• 539-44-6 N-4-methylphenylhydrazine 
• 99-91-2 para-chloroacetophenone 
• 36640-46-7 3-(4-chloro-phenyl)-1-p-tolyl-1H-pyrazole-4-carbaldehyde 

Relevant academic research and scientific papers

Synthesis of some 2-({(2E)-3-(1,3-substituted diphenyl-1H-pyrazol-4-yl) prop-2-enoyl} amino) benzoic acids as antiinflammatory agents

Vilsmeier-Haack reaction of substituted phenyl hydrazone derivatives (1a-j) afforded 1,3-substituted diphenyl-1H-pyrazole-4-carbaldehydes (2a-j). Compounds (2a-j) on condensation with malonic acid gave (2E)-3-(1,3-substituted diphenyl-1H-pyrazol-4-yl) acrylic acids (3a-j) which on reaction with thionyl chloride afforded acryloyl chlorides. The reaction of acryloyl chlorides with anthranilic acid gave 2-({(2E)-3-(1,3-substituted diphenyl-1H-pyrazol-4-yl) prop-2-enoyl} amino) benzoic acids (4a-j) in good yields. The structures of the newly synthesized compounds have been confirmed on the basis of physical and spectral data. Some of the synthesized compounds have shown significant antiiflammatory actiivty.