1401971-06-9Relevant academic research and scientific papers
Gold(I)-Catalyzed Intramolecular Carbon-Oxygen Bond Cleavage Reaction via Gold Carbenes Derived from Vinylidenecyclopropanes
Li, De-Yao,Wei, Yin,Shi, Min
supporting information, p. 3002 - 3009 (2016/10/09)
Under gold(I) catalysis, the in situ generated gold carbene from vinylidenecyclopropanes bearing a methoxymethyl group can undergo an intramolecular nucleophilic attack to give the carbon-oxygen bond cleavage product in good yield within 15 min. and different phosphine ligands could control both Z- and E-configurations, respectively. The reaction mechanism has been clarified on the basis of deuterium- and18O-labeling experiments. This method provides a new and efficient approach to stereoselectively synthesize alkylidenecyclobutanones under mild conditions. (Figure presented.).
A concise synthesis of chiral indanes as α1A adrenoceptor partial agonists
Roberts, Lee R.,Corbett, Matthew S.,Fussell, Steven J.,Hitzel, Laure,Jessiman, Alan S.,Mason, Helen J.,Osborne, Rachel,Ralph, Michael J.,Stennett, Adam S.D.,Wheeler, Simon,Storer, R. Ian
supporting information, p. 6546 - 6550 (2015/11/09)
The synthesis of a series of chiral indanes with reported α1A partial agonist activity is outlined, applying a rhodium catalysed cyclisation for template construction. This method was extended to the asymmetric synthesis of lead compound PF-037
Novel 2-imidazoles as potent, selective and CNS penetrant α1A adrenoceptor partial agonists
Roberts, Lee R.,Bryans, Justin,Conlon, Kelly,McMurray, Gordon,Stobie, Alan,Whitlock, Gavin A.
scheme or table, p. 6437 - 6440 (2009/10/01)
A novel series of central nervous system (CNS) penetrant indane 2-imidazoles have been identified as potent, partial agonists of the α1A adrenergic receptor, having good selectivity over the α1B, α1D and α2 sub-
