1401971-06-9Relevant academic research and scientific papers
Gold(I)-Catalyzed Intramolecular Carbon-Oxygen Bond Cleavage Reaction via Gold Carbenes Derived from Vinylidenecyclopropanes
Li, De-Yao,Wei, Yin,Shi, Min
supporting information, p. 3002 - 3009 (2016/10/09)
Under gold(I) catalysis, the in situ generated gold carbene from vinylidenecyclopropanes bearing a methoxymethyl group can undergo an intramolecular nucleophilic attack to give the carbon-oxygen bond cleavage product in good yield within 15 min. and different phosphine ligands could control both Z- and E-configurations, respectively. The reaction mechanism has been clarified on the basis of deuterium- and18O-labeling experiments. This method provides a new and efficient approach to stereoselectively synthesize alkylidenecyclobutanones under mild conditions. (Figure presented.).
A concise synthesis of chiral indanes as α1A adrenoceptor partial agonists
Roberts, Lee R.,Corbett, Matthew S.,Fussell, Steven J.,Hitzel, Laure,Jessiman, Alan S.,Mason, Helen J.,Osborne, Rachel,Ralph, Michael J.,Stennett, Adam S.D.,Wheeler, Simon,Storer, R. Ian
, p. 6546 - 6550 (2015/11/09)
The synthesis of a series of chiral indanes with reported α1A partial agonist activity is outlined, applying a rhodium catalysed cyclisation for template construction. This method was extended to the asymmetric synthesis of lead compound PF-037
Novel 2-imidazoles as potent, selective and CNS penetrant α1A adrenoceptor partial agonists
Roberts, Lee R.,Bryans, Justin,Conlon, Kelly,McMurray, Gordon,Stobie, Alan,Whitlock, Gavin A.
scheme or table, p. 6437 - 6440 (2009/10/01)
A novel series of central nervous system (CNS) penetrant indane 2-imidazoles have been identified as potent, partial agonists of the α1A adrenergic receptor, having good selectivity over the α1B, α1D and α2 sub-
