1402143-59-2Relevant academic research and scientific papers
Discovery of Potent Inhibitors against P-Glycoprotein-Mediated Multidrug Resistance Aided by Late-Stage Functionalization of a 2-(4-(Pyridin-2-yl)phenoxy)pyridine Analogue
Ma, Yao,Yin, Dawei,Ye, Jingjia,Wei, Xiduan,Pei, Yameng,Li, Xueyuan,Si, Guangxu,Chen, Xuan-Yu,Chen, Zhe-Sheng,Dong, Yi,Zou, Feng,Shi, Wei,Qiu, Qianqian,Qian, Hai,Liu, Gang
, p. 5458 - 5476 (2020)
SIS3 is a specific inhibitor of Smad3 that inhibits the TGFβ1-induced phosphorylation of Smad3. In this article, a variety of SIS3 derivatives were designed and synthesized to discover potential inhibitors against P-glycoprotein-mediated multidrug resistance aided by late-stage functionalization of a 2-(4-(pyridin-2-yl)phenoxy)pyridine analogue. A novel class of potent P-gp reversal agents were investigated, and a lead compound 37 was identified as a potent P-gp reversal agent with strong bioactivity and outstanding affinity for P-gp.
INHIBITORS OF VIRAL REPLICATION, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES
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Page/Page column 63, (2012/10/18)
The present invention relates to compounds of formula (1) as claimed in claim 1, their use in the treatment or the prevention of viral disorders, including HIV. (Formula I)
