18112-51-1

Upstream product

• 3558-24-5 1-methyl-2-phenyl-1H-indole 
• 4755-77-5 Ethyl oxalyl chloride 
• 64-17-5 ethanol 

Downstream Products

• 401934-74-5 C₁₇H₁₇NO 
• 1402143-58-1 ethoxy-(1-methyl-2-phenyl-1H-indol-3-yl)-acetic acid 
• 1402143-59-2 ethyl hydroxy-(1-methyl-2-phenyl-1H-indol-3-yl)-acetate 

Relevant academic research and scientific papers

A furoindoline synthesis by remote radical functionalization

The preliminary results of an investigation toward a synthesis of furoindolines from 3-(2-hydroxyethyl)indolines by remote radical functionalization are described. Using an oxidative radical cyclization, it was discovered that the intramolecular hydrogen abstraction was only successful when the resulting radical (and hence carbocation) was resonance stabilized by adjacent tertiary amine and phenyl groups. The successful cyclization affords diastereomeric furoindolines, one of which contains a highly strained trans-fused 5,5-ring system. This furoindoline synthesis contains a rare example of an alkoxy radical promoted hydrogen atom transfer of a proton attached to a nitrogen-substituted carbon.

INHIBITORS OF VIRAL REPLICATION, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES

The present invention relates to compounds of formula (1) as claimed in claim 1, their use in the treatment or the prevention of viral disorders, including HIV. (Formula I)