1402238-32-7

Basic information

• Product Name: 4-(2-Fluorophenoxy)phenylboronic acid
• Synonyms: 4-(2-Fluorophenoxy)phenylboronic acid;IQNYGJLCROJQSI-UHFFFAOYSA-N
• CAS NO: 1402238-32-7
• Molecular Formula: C₁₂H₁₀BFO₃
• Molecular Weight: 232.0154032
• Mol File: 1402238-32-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 356.1±52.0 °C(Predicted)
• Appearance: /
• Density: 1.30±0.1 g/cm3(Predicted)
• Storage Temp.: Refrigerated.
• PKA: 8.53±0.16(Predicted)
• CAS DataBase Reference: 4-(2-Fluorophenoxy)phenylboronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-Fluorophenoxy)phenylboronic acid(1402238-32-7)
• EPA Substance Registry System: 4-(2-Fluorophenoxy)phenylboronic acid(1402238-32-7)

Safety Data

• Hazardous Substances Data: 1402238-32-7(Hazardous Substances Data)

Usage

General Description

4-(2-Fluorophenoxy)phenylboronic acid is a chemical compound with the formula C12H10BFO3. It is a boronic acid derivative with a fluorophenoxyphenyl group attached. 4-(2-Fluorophenoxy)phenylboronic acid is commonly used in organic synthesis, particularly in the formation of carbon-carbon bonds through Suzuki-Miyaura cross-coupling reactions. It is also used in the development of pharmaceuticals and agrochemicals due to its ability to modulate biological processes and enzyme functions. Additionally, 4-(2-Fluorophenoxy)phenylboronic acid has potential applications in the field of materials science and catalysis.

Upstream product

• 5467-74-3 4-Bromophenylboronic acid 
• 1478-03-1 1-(2-fluorophenoxy)-4-nitrobenzene 
• 5419-55-6 Triisopropyl borate 
• 851199-57-0 1-fluoro-2-(4-iodophenoxy)-benzene 
• 305801-12-1 4-(2-fluorophenoxy)benzenamine 
• 350-46-9 4-Fluoronitrobenzene 
• 367-12-4 2-fluorophenol 

Downstream Products

• 1414356-46-9 tert-butyl (3R)-3-[4-amino-3-[4-(2-fluorophenoxy)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate 
• 1414356-45-8 (R)-2-(3-(4-amino-3-(4-(2-fluorophenoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carbonyl)-3-cyclopropylacrylonitrile 
• 1414356-47-0 3-[4-(2-fluorophenoxy)phenyl]-1-((3R)-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine 
• 1414356-48-1 3-[(3R)-3-[4-amino-3-[4-(2-fluorophenoxy)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]-3-oxopropanenitrile 

Relevant articles and documents

CYCLIC MOLECULES AS BRUTON'S TYROSINE KINASE INHIBITOR

The present invention relates to a novel molecule with protein tyrosine kinase inhibitory activity, and the synthesis and usage thereof. Specifically, the present invention relates to compound by formula A, pharmaceutically acceptable salts, hydrates or solvates thereof, and the synthesis and usage thereof.

TREATMENT OF DRY EYE

The present disclosure provides a method of treating dry eye by inhibition of Bruton's tyrosine kinase (hereinafter "BTK") inhibitors, pharmaceutical formulations comprising the same, and processes for preparing such compounds.

TYROSINE KINASE INHIBITORS

The present disclosure provides compounds and pharmaceutically acceptable salts thereof that are tyrosine kinase inhibitors, in particular BLK, BMX, EGFR, HER2, HER4, ITK, TEC, BTK, and TXK and are therefore useful for the treatment of diseases treatable by inhibition of tyrosine kinases such as cancer and inflammatory diseases such as arthritis, and the like. Also provided are pharmaceutical compositions containing such compounds and pharmaceutically acceptable salts thereof and processes for preparing such compounds and pharmaceutically acceptable salts thereof.