140241-90-3

Upstream product

• 89-98-5 2-chloro-benzaldehyde 
• 105-56-6 ethyl 2-cyanoacetate 
• 123-11-5 4-methoxy-benzaldehyde 
• 64-17-5 ethanol 
• 107-91-5 cyanoacetic acid amide 
• 70380-66-4 2-chlorobenzaldehyde dimethyl acetal 

Downstream Products

• 6954-40-1 3-(2-Chlorophenyl)succinic acid 
• 77198-26-6 2-Amino-6-(2-chloro-phenyl)-1,3-dicyano-4-phenyl-cyclohexa-2,4-dienecarboxylic acid ethyl ester 
• 77198-25-5 2-Amino-6-(2-chloro-phenyl)-1,3-dicyano-4-p-tolyl-cyclohexa-2,4-dienecarboxylic acid ethyl ester 
• 129115-59-9 C₁₇H₁₂ClN₃O₂ 
• 89-98-5 2-chloro-benzaldehyde 
• 489414-14-4 5-[1-(2-Chloro-phenyl)-meth-(Z)-ylidene]-3-(4-methyl-benzyl)-thiazolidine-2,4-dione 
• 15162-37-5 ethyl 2-(o-Chlorobenzyl)-Cyanoacetate 
• 333341-09-6 2-amino-4-(2-chlorophenyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carboxylic acid ethyl ester 
• 1325732-58-8 diethyl 6-(2-chlorophenyl)-1-cyanocyclohex-3-ene-1,3-dicarboxylate 

Relevant academic research and scientific papers

LiCl catalyzed Knoevenagel condensation: Comparative study of conventional method vs microwave irradiation

LiCl catalyzes the condensation of aromatic aldehydes with active methylene compounds either in NMP or DMF at room temperature or under microwave irradiation in dry media to produce olefinic products in high yields.

Microwave-assisted Knoevenagel condensation in aqueous over triazine-based microporous network

A high nitrogen-containing triazine-based microporous polymeric (TMP) network was used as an efficient metal-free catalyst for Knoevenagel condensation of ethylcyanoacetate with aromatic aldehydes. The reactions were performed in water as an environmental

Synthesis and characterization of P4VP/SBA-15 composite by in situ polymerization

Poly(4-vinylpyridine)/SBA-15 (P4VP/SBA-15) composites with various amounts of SBA-15 were prepared and characterized. The physical and chemical properties of P4VP/SBA-15 were investigated by XRD, BET, FT-IR, TGA, and SEM techniques. The catalytic performa

Amines functionalized C60 as solid base catalysts for Knoevenagel condensation with high activity and stability

Four kinds of amines functionalized C60 were prepared through an amination reaction of C60 with organic amines. Their surface structures and basic properties were studied by Fourier transform infrared spectrometry (FTIR), X-ray photoelectron spectroscopy (XPS) and temperature-programmed desorption (TPD) with CO2 as the probe molecule. When used as solid base catalysts, N-aminoethylpiperazine functionalized C60 (C60-AEP) showed the best catalytic activity in the Knoevenagel condensation reaction due to the highest basic strength. In addition, the C60-AEP catalyst also showed impressive catalytic stability. All these features endowed C60-AEP with characteristics of both homogeneous and heterogeneous catalysts. More interestingly, chiral l-lysine functionalized C60 (C60-L-L) can be used for asymmetric intermolecular aldol reactions.

Polyoxoniobates as a superior Lewis base efficiently catalyzed Knoevenagel condensation

The outstanding basicity of negative charged Lindqvist type Polyoxoniobate K7HNb6O19·13H2O (Nb6) have been proved experimentally as well as by theoretical NBO calculations, the results insights high electron density on terminal and bridging oxygen atoms of niobate anion. The most negative Natural Bond Orbital charge (NBO) of oxygen in Nb6 is ?1.001, which is a much more negative value than those reported in other polyoxometalates, that corroborates its high basicity thus likely to be employed as a strong base catalyst. Experimental study suggests that Nb6 can efficiently catalyze Knoevenagel condensation of various carbonyl compounds with active methylene compounds neglecting the steric and electronic effect of aromatic aldehydes under mild conditions. Kinetic test shows that Knoevenagel condensation of benzaldehyde with ethyl cyanoacetate exhibits second-order kinetics in the presence of Nb6 and the calculated activation energy is 43.3 kJ mol?1. Meanwhile, a proper mechanism according to the NBO study speculates that the most negative charged terminal oxygens in Nb6 would be pivotal in this transformation.

Nano-Fe3O4 encapsulated-silica particles bearing 3-aminopropyl group as a magnetically separable catalyst for efficient knoevenagel condensation of aromatic aldehydes with active methylene compounds

Knoevenagel condensation of aromatic aldehydes with active methylene compounds such as malononitrile, ethylcyanoacetate, benzimidazol-2-acetonitrile and benzothiazole-2-acetonitrile proceeded very smoothly, catalyzed by nano-Fe3O4 encapsulated-silica particles supported primary amine. Both reaction time and yield are satisfying. The advantages of this catalyst are ease of preparation, non-toxicity, low cost, ease of handling and recyclability. Copyright

The Knoevenagel condensation of aromatic aldehydes with malononitrile or ethyl cyanoacetate in the presence of CTMAB in water

A new route of Knoevenagel condensation of aldehydes with malononitrile or ethyl cyanoacetate in the presence of CTMAB in water is described. CTMAB is the most effective catalyst to increase yield among CTMAB, BTEAC and TBAI.

Highly active zinc oxide-supported lithium oxide catalyst for solvent-free Knoevenagel condensation

Li2O/ZnO catalyst was prepared by wet impregnation method and characterized by XRD, SEM, EDX, FTIR, BET surface area and UV-Vis diffuse reflectance spectroscopy. This study revealed a decrease in average particle size and change in the shape of

Simple, efficient, and green procedure for the knoevenagel condensation catalyzed by ethylenediammonium diacetate under solvent-free conditions

A simple, efficient, and green procedure for Knoevenagel condensation of aromatic aldehydes with malononitrile and ethyl cyanoacetate catalyzed by ethylenediammonium diacetate under solvent-free conditions at room temperature is reported. This method give

Polystyrene-supported pyridinium chloroaluminate ionic liquid as a new heterogeneous Lewis acid catalyst for Knoevenagel condensation

Non-hygroscopic polystyrene-supported chloroaluminate ionic liquid was prepared from the reaction of Merrifield resin with pyridine followed by reaction with aluminium chloride. This Lewis acidic ionic liquid is an environmentally friendly heterogeneous c