140244-00-4

Basic information

• Product Name: Benzene, 1,1'-(1-fluoro-1,4-butanediyl)bis-
• CAS NO: 140244-00-4
• Molecular Formula: C16H17F
• Molecular Weight: 228.309
• Mol File: 140244-00-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzene, 1,1'-(1-fluoro-1,4-butanediyl)bis-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1,1'-(1-fluoro-1,4-butanediyl)bis-(140244-00-4)
• EPA Substance Registry System: Benzene, 1,1'-(1-fluoro-1,4-butanediyl)bis-(140244-00-4)

Safety Data

• Hazardous Substances Data: 140244-00-4(Hazardous Substances Data)

Upstream product

• 591-51-5 phenyllithium 
• 100-42-5 styrene 
• 3070-40-4 β-phenylpropionyl peroxide 
• 591-50-4 iodobenzene 
• 98-80-6 phenylboronic acid 
• 1821-12-1 4-Phenylbutyric acid 
• 123133-12-0 1-chloro-1-fluoro-4-phenylbutyl phenyl sulfoxide 
• 5407-91-0 1,4-diphenylbutan-1-one 
• 4119-41-9 1-iodo-3-phenylpropan 

Relevant articles and documents

Merging Visible-Light Photocatalysis and Transition-Metal Catalysis in Three-Component Alkyl-Fluorination of Olefins with a Fluoride Ion

The light-induced, Ru-catalyzed three-component alkyl-fluorination of olefins under mild reaction conditions is reported. This carbofluorination reaction features a wide substrate scope and good functional group tolerance. A key advantage of this photoredox reaction is the use of nucleophilic fluoride and generic alkyl groups. Late-stage functionalizations are achieved, and a copper-assisted oxidative quenching mechanism is proposed based on the mechanistic studies.

Nickel-Catalyzed Reductive Cross-Coupling of Aryl Halides with Monofluoroalkyl Halides for Late-Stage Monofluoroalkylation

A combinatorial nickel-catalyzed monofluoroalkylation of aryl halides with unactivated fluoroalkyl halides by reductive cross-coupling has been developed. This method demonstrated high efficiency, mild conditions, and excellent functional-group tolerance, thus enabling the late-stage monofluoroalkylation of diverse drugs. The key to success was the combination of diverse readily available bidentate and monodentate pyridine-type nitrogen ligands with nickel, which in situ generated a variety of readily tunable catalysts to promote fluoroalkylation with broad scope with respect to both coupling partners. This combinatorial catalysis strategy offers a solution for nickel-catalyzed reductive cross-coupling reactions and provides an efficient way to synthesize fluoroalkylated druglike molecules for drug discovery.