1402569-27-0

Basic information

• Product Name: methyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(2,4,5-trifluorophenyl)-butanoate
• Synonyms: methyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(2,4,5-trifluorophenyl)-butanoate
• CAS NO: 1402569-27-0
• Molecular Weight: 358.165
• Mol File: 1402569-27-0.mol

Chemical Properties

• CAS DataBase Reference: methyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(2,4,5-trifluorophenyl)-butanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(2,4,5-trifluorophenyl)-butanoate(1402569-27-0)
• EPA Substance Registry System: methyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(2,4,5-trifluorophenyl)-butanoate(1402569-27-0)

Safety Data

• Hazardous Substances Data: 1402569-27-0(Hazardous Substances Data)

Upstream product

• 1352613-28-5 2,4,5-trifluorobenzene magnesium chloride 
• 1117-71-1 methyl-4-bromo-2-butenoate 
• 1260029-44-4 (E)-4-(2,4,5-trifluoro-phenyl)-but-2-enoic acid methyl ester 
• 73183-34-3 bis(pinacol)diborane 
• 327-52-6 1-bromo-2,4,5-trifluorobenzene 
• 367-23-7 1,2,4-trifluorobenzene 

Downstream Products

• 1253056-13-1 methyl 3-hydroxy-4-(2,4,5-trifluorophenyl)butanoate 
• 1402569-99-6 methyl 3-acetamido-4-(2,4,5-trifluorophenyl)butanoate 
• 1253055-92-3 methyl 3-amino-4-(2,4,5-trifluorophenyl)butanoate 
• 1369995-39-0 methyl 3-benzylamino-4-(2,4,5-trifluorophenyl)butanoate 

Relevant articles and documents

Preparation of Optically Pure ?-Amino Acid Type Active Pharmaceutical Ingredients and Intermediates thereof

The present invention relates to the preparation of optically resolved chiral compounds of β-amino acid type active pharmaceutical ingredients (API), more specifically to β-aminobutyryl substituted compounds and especially β-aminobutyryl compounds having γ-bound aryl groups. The present invention more particularly relates to the preparation of enantiomerically enriched chiral compounds useful as intermediates for the preparation of anti-diabetic agents, preferably sitagliptin.

PREPARATION OF OPTICALLY PURE ?-AMINO ACID TYPE ACTIVE PHARMACEUTICAL INGREDIENTS AND INTERMEDIATES THEREOF

The present invention relates to the preparation of optically resolved chiral compounds of β-amino acid type active pharmaceutical ingredients (API), more specifically to β-aminobutyryl substituted compounds and especially β-aminobutyryl compounds having γ-bound aryl groups. The present invention more particularly relates to the preparation of enantiomerically enriched chiral compounds useful as intermediates for the preparation of anti-diabetic agents, preferably sitagliptin.

Basic CuCO3/ligand as a new catalyst for 'on water' borylation of Michael acceptors, alkenes and alkynes: Application to the efficient asymmetric synthesis of β-alcohol type sitagliptin side chain

The efficient 'on water' β-borylation using bis(pinacolato)diboron agent was achieved with a newly developed catalytic system based on basic copper carbonate and various ligands. The catalytic system was used for β-borylation of various Michael acceptors,

?-BORATION OF ALKENE AND ALKYNE INTERMEDIATES

The present invention relates to the field of organic chemistry, and in particular to the preparation of β-borated compounds. These β-borated compounds can be used as intermediates in the synthesis pharmaceutically active agents such as sitagliptin.

PREPARATION OF SITAGLIPTIN INTERMEDIATES

The invention relates to the preparation of chiral compounds, in particular to the preparation of chiral compounds which may be used as intermediates for the preparation of anti-diabetic agents, preferably sitagliptin.

Preparation of sitagliptin intermediates

The invention relates to the preparation of chiral compounds, in particular to the preparation of chiral compounds which may be used as intermediates for the preparation of anti-diabetic agents, preferably sitagliptin.