1402569-99-6

Basic information

• Product Name: methyl 3-acetamido-4-(2,4,5-trifluorophenyl)butanoate
• Synonyms: methyl 3-acetamido-4-(2,4,5-trifluorophenyl)butanoate
• CAS NO: 1402569-99-6
• Molecular Weight: 289.254
• Mol File: 1402569-99-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: methyl 3-acetamido-4-(2,4,5-trifluorophenyl)butanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-acetamido-4-(2,4,5-trifluorophenyl)butanoate(1402569-99-6)
• EPA Substance Registry System: methyl 3-acetamido-4-(2,4,5-trifluorophenyl)butanoate(1402569-99-6)

Safety Data

• Hazardous Substances Data: 1402569-99-6(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 1402569-27-0 methyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(2,4,5-trifluorophenyl)-butanoate 
• 1253056-13-1 methyl 3-hydroxy-4-(2,4,5-trifluorophenyl)butanoate 
• 367-23-7 1,2,4-trifluorobenzene 
• 1352613-28-5 2,4,5-trifluorobenzene magnesium chloride 
• 1260029-44-4 (E)-4-(2,4,5-trifluoro-phenyl)-but-2-enoic acid methyl ester 
• 1117-71-1 methyl-4-bromo-2-butenoate 
• 75-05-8 acetonitrile 
• 327-52-6 1-bromo-2,4,5-trifluorobenzene 

Relevant articles and documents

Truce–Smiles Rearrangements by Strain Release: Harnessing Primary Alkyl Radicals for Metal-Free Arylation

The ring-opening of 3-aminocyclobutanone oximes enables easy generation of primary alkyl radicals, capable of undergoing an unprecedented strain-release, desulfonylative radical Truce–Smiles rearrangement, providing divergent access to valuable 1,3 diamin

PREPARATION OF OPTICALLY PURE ?-AMINO ACID TYPE ACTIVE PHARMACEUTICAL INGREDIENTS AND INTERMEDIATES THEREOF

The present invention relates to the preparation of optically resolved chiral compounds of β-amino acid type active pharmaceutical ingredients (API), more specifically to β-aminobutyryl substituted compounds and especially β-aminobutyryl compounds having γ-bound aryl groups. The present invention more particularly relates to the preparation of enantiomerically enriched chiral compounds useful as intermediates for the preparation of anti-diabetic agents, preferably sitagliptin.

Preparation of sitagliptin intermediates

The invention relates to the preparation of chiral compounds, in particular to the preparation of chiral compounds which may be used as intermediates for the preparation of anti-diabetic agents, preferably sitagliptin.