1402687-67-5

Basic information

• Product Name: 3-methyl-N-(4-(piperidin-1-yl)phenethyl)-1H-indole-2-sulfonamide
• Synonyms: 3-methyl-N-(4-(piperidin-1-yl)phenethyl)-1H-indole-2-sulfonamide
• CAS NO: 1402687-67-5
• Molecular Weight: 397.541
• Mol File: 1402687-67-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-methyl-N-(4-(piperidin-1-yl)phenethyl)-1H-indole-2-sulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methyl-N-(4-(piperidin-1-yl)phenethyl)-1H-indole-2-sulfonamide(1402687-67-5)
• EPA Substance Registry System: 3-methyl-N-(4-(piperidin-1-yl)phenethyl)-1H-indole-2-sulfonamide(1402687-67-5)

Safety Data

• Hazardous Substances Data: 1402687-67-5(Hazardous Substances Data)

Upstream product

• 1394430-90-0 3-methyl-1-(phenylsulfonyl)-N-(4-(piperidin-1-yl)phenethyl)-1H-indole-2-sulfonamide 
• 83-34-1 3-Methylindole 
• 26304-51-8 ethyl 3-methyl-indole-2-carboxylate 
• 100-63-0 phenylhydrazine 
• 1394430-58-0 3-methyl-1-(phenylsulfonyl)-1H-indole-2-sulfonyl chloride 
• 1394430-57-9 lithium 3-methyl-1-(phenylsulfonyl)-1H-indole-2-sulfinate 

Relevant articles and documents

Development of indole sulfonamides as cannabinoid receptor negative allosteric modulators

Existing CB1 negative allosteric modulators (NAMs) fall into a limited range of structural classes. In spite of the theoretical potential of CB1 NAMs, published in vivo studies have generally not been able to demonstrate the expected therapeutically-relevant CB1-mediated effects. Thus, a greater range of molecular tools are required to allow definitive elucidation of the effects of CB1 allosteric modulation. In this study, we show a novel series of indole sulfonamides. Compounds 5e and 6c (ABD1075) had potencies of 4 and 3?nM respectively, and showed good oral exposure and CNS penetration, making them highly versatile tools for investigating the therapeutic potential of allosteric modulation of the cannabinoid system.