26304-51-8

Basic information

• Product Name: ETHYL3-METHYL-2-INDOLECARBOXYLATE
• Synonyms: ETHYL3-METHYL-2-INDOLECARBOXYLATE;3-Methyl-1H-indole-2-carboxylic acid ethyl ester;Ethyl 3-methylindole-2-carboxylate;1H-Indole-2-carboxylic acid, 3-Methyl-, ethyl ester;3-Methyl-Ethyl indole-2-carboxylate;3-methylindole-2-carboxylate
• CAS NO: 26304-51-8
• Molecular Formula: C₁₂H₁₃NO₂
• Molecular Weight: 203.23712
• Mol File: 26304-51-8.mol
• Article Data: 22

Chemical Properties

• Melting Point: 134-136℃
• Boiling Point: 344℃
• Flash Point: 162℃
• Appearance: /
• Density: 1.177
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 15.31±0.30(Predicted)
• CAS DataBase Reference: ETHYL3-METHYL-2-INDOLECARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL3-METHYL-2-INDOLECARBOXYLATE(26304-51-8)
• EPA Substance Registry System: ETHYL3-METHYL-2-INDOLECARBOXYLATE(26304-51-8)

Safety Data

• Hazardous Substances Data: 26304-51-8(Hazardous Substances Data)

Usage

General Description

ETHYL3-METHYL-2-INDOLECARBOXYLATE is a chemical compound with the molecular formula C14H15NO2. It is a derivative of indole, which is a heterocyclic aromatic organic compound. ETHYL3-METHYL-2-INDOLECARBOXYLATE is commonly used in the pharmaceutical industry as a building block for the synthesis of various drugs and pharmaceutical products. It is also used in organic synthesis and in the production of agrochemicals. ETHYL3-METHYL-2-INDOLECARBOXYLATE has potential applications in the development of new pharmaceuticals and other chemical products due to its versatile reactivity and functional group compatibility. However, it is important to handle this compound with caution and follow proper safety protocols due to its potential health hazards.

Upstream product

• 167479-51-8 2-phenylhydrazono-butyric acid ethyl ester 
• 10590-73-5 3-methylindole-2-carboxylic acid 
• 77-83-8 fraeseol 
• 2142-69-0 2-bromophenyl methyl ketone 
• 105-56-6 ethyl 2-cyanoacetate 
• 15933-07-0 Ethyl 2-oxobutanoate 
• 100-63-0 phenylhydrazine 
• 62-53-3 aniline 
• 63158-54-3 2-(2-(ethoxycarbonyl)-1H-indol-3-yl)acetic acid 
• 83-34-1 3-Methylindole 
• 64-17-5 ethanol 
• 558-13-4 carbon tetrabromide 
• 637328-04-2 EtO₂CCHC(Me)(o-BrC₆H₄) 
• 52194-36-2 ethyl 3-nitrobut-2-enoate 

Downstream Products

• 1401619-28-0 ethyl 1-(4-chlorobenzyl)-3-methyl-1H-indole-2-carboxylate 
• 1401619-30-4 1-(4-chlorobenzyl)-3-methyl-1H-indole-2-carboxylic acid 
• 1401619-10-0 N-benzyl-1-(1-(4-chlorobenzyl)-3-methyl-1H-indole-2-carbonyl)piperidine-4-carboxamide 
• 1402687-68-6 N-(4-(dimethylamino)phenethyl)-3-methyl-1H-indole-2-sulfonamide 
• 1394430-91-1 N-(4-(dimethylamino)phenethyl)-3-methyl-1-(phenylsulfonyl)-1H-indole-2-sulfonamide 
• 1402687-67-5 3-methyl-N-(4-(piperidin-1-yl)phenethyl)-1H-indole-2-sulfonamide 
• 1394430-90-0 3-methyl-1-(phenylsulfonyl)-N-(4-(piperidin-1-yl)phenethyl)-1H-indole-2-sulfonamide 
• 1394430-77-3 N-(biphenyl-4-ylmethyl)-3-methyl-1H-indole-2-sulfonamide 
• 1394430-76-2 N-(biphenyl-4-ylmethyl)-3-methyl-1-(phenylsulfonyl)-1H-indole-2-sulfonamide 
• 83-34-1 3-Methylindole 
• 1394430-80-8 3-methyl-1-(phenylsulfonyl)-N-(pyridin-3-ylmethyl)-1H-indole-2-sulfonamide 
• 1394430-78-4 3-methyl-1-(phenylsulfonyl)-N-(pyridin-2ylmethyl)-1H-indole-2-sulfonamide 
• 1394430-66-0 5-chloro-N-(4-chlorobenzyl)-3-ethyl-1-(phenylsulfonyl)-1H-indole-2-sulfonamide 
• 1394430-89-7 3-methyl-N-phenethyl-1H-indole-2-sulfonamide 

Relevant articles and documents

β-nitroacrylates as useful building blocks for the synthesis of alkyl indole-2-carboxylates

Polyfunctionalized alkyl indole 2-carboxylates can be easily synthesized starting form β-nitroacrylates and o-bromoanilines through an addition-elimination process followed by an intramolecular palladium-catalyzed Heck reaction. Georg Thieme Verlag Stuttg

5-MEMBERED HETEROCYCLE FUSED WITH [3,4-D]PYRIDAZINONE, AND MANUFACTURING METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION THEREOF

The present invention provides a compound comprising a 5-membered heterocycle fused with a pyridazinone, wherein the compound is used as an FGFR kinase inhibitor, and a manufacturing method and application thereof. The invention specifically provides a co

Development of indole sulfonamides as cannabinoid receptor negative allosteric modulators

Existing CB1 negative allosteric modulators (NAMs) fall into a limited range of structural classes. In spite of the theoretical potential of CB1 NAMs, published in vivo studies have generally not been able to demonstrate the expected therapeutically-relevant CB1-mediated effects. Thus, a greater range of molecular tools are required to allow definitive elucidation of the effects of CB1 allosteric modulation. In this study, we show a novel series of indole sulfonamides. Compounds 5e and 6c (ABD1075) had potencies of 4 and 3?nM respectively, and showed good oral exposure and CNS penetration, making them highly versatile tools for investigating the therapeutic potential of allosteric modulation of the cannabinoid system.