1402822-34-7

Upstream product

• 1402822-32-5 (3aR,4R,6R,6aR)-4-(4-amino-2-oxopyrimidin-1(2H)-yl)-6-((R)-1-hydroxyethyl)-2-methoxytetrahydrofuro[3,4-d][1,3]dioxole-4-carbonitrile 
• 1402821-81-1 (2R,3R,4S,5R)-2-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxy-5-((R)-1-hydroxyethyl)tetrahydrofuran-2-carbonitrile 
• 1402822-33-6 (2S)-isopropyl2-(((S)-((1R)-1-((3aR,4S,6R,6aR)-6-(4-amino-2-oxopyrimidin-1(2H)-yl)-6-cyano-2-methoxytetrahydrofuro[3,4-d][1,3]dioxol-4-yl)ethoxy)(phenoxy)phosphoryl)amino)propanoate 
• 1256490-31-9 (S)-2-[(S)-(4-nitro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester 
• 39613-92-8 alanine isopropyl ester hydrochloride 
• 100-02-7 4-nitro-phenol 

Relevant academic research and scientific papers

Synthesis of 1′-C-Cyano Pyrimidine Nucleosides and Characterization as HCV Polymerase Inhibitors

Ribose modified 1′-C-cyano pyrimidine nucleosides were synthesized. A silver triflate mediated Vorbrüggen reaction was used to generate the nucleoside scaffold and follow-up chemistry provided specific ribose modified analogs. Nucleosides and phosphoramid

1'-SUBSTITUTED PYRIMIDINE N-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT

Provided are compounds of Formula I: nucleosides, nucleoside phosphates and prodrugs thereof, wherein R6 is CN, ethenyl, 2-haloethen-1-yl, or (C2-C8)-alkyn-1-yl. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections.