1402931-91-2

Basic information

• Product Name: C₂₆H₂₃ClO₇
• Synonyms: C₂₆H₂₃ClO₇
• CAS NO: 1402931-91-2
• Molecular Weight: 482.917
• Mol File: 1402931-91-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₆H₂₃ClO₇(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₆H₂₃ClO₇(1402931-91-2)
• EPA Substance Registry System: C₂₆H₂₃ClO₇(1402931-91-2)

Safety Data

• Hazardous Substances Data: 1402931-91-2(Hazardous Substances Data)

Upstream product

• 874202-33-2 7-(benzyloxy)-3-hydroxy-5-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one 
• 1402931-29-6 1-(4-(benzyloxy)-2-hydroxy-6-methoxyphenyl)-2-hydroxyethanone 
• 1402931-76-3 (1R,2R,3S,3aR,8bS)-methyl 6-chloro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3,3a,8b-tetrahydro-1H-benzo[b]-cyclopenta[d]furan-2-carboxylate 
• 39548-89-5 1-(4-(benzyloxy)-2-hydroxy-6-methoxyphenyl)ethan-1-one 
• 1402931-62-7 (1R,2R,3S,3aR,8bS)-methyl 1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-6-(trifluoromethylsulfonyloxy)-2,3,3a,8b-tetrahydro-1H-benzo[b]cyclopenta[d]furan-2-carboxylate 
• 681294-57-5 1-(4-(benzyloxy)-2-hydroxy-6-methoxyphenyl)ethanone 
• 110506-85-9 7-(benzyloxy)-5-hydroxy-2-phenyl-4H-chromen-4-one 
• 480-40-0 5,7-dihydroxy-2-phenyl-chromen-4-one 
• 960365-65-5 (1R,2R,3S,3aR,8bS)-methyl 1,6,8b-trihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3,3a,8b-tetrahydro-1H-benzo[b]-cyclopenta[d]furan-2-carboxylate 
• 1402931-30-9 7-(benzyloxy)-5-methoxy-2-(4-methoxyphenyl)-4-oxo-4H-chromen-3-yl 4-methoxybenzoate 

Downstream Products

• 1402931-85-4 (1R,2R,3S,3aR,8bS)-6-chloro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-3-phenyl-2,3,3a,8b-tetrahydro-1H-benzo[b]cyclopenta[d]furan-2-carboxamide 

Relevant articles and documents

Synthetic silvestrol analogues as potent and selective protein synthesis inhibitors

Misregulation of protein translation plays a critical role in human cancer pathogenesis at many levels. Silvestrol, a cyclopenta[b]benzofuran natural product, blocks translation at the initiation step by interfering with assembly of the eIF4F translation complex. Silvestrol has a complex chemical structure whose functional group requirements have not been systematically investigated. Moreover, silvestrol has limited development potential due to poor druglike properties. Herein, we sought to develop a practical synthesis of key intermediates of silvestrol and explore structure-activity relationships around the C6 position. The ability of silvestrol and analogues to selectively inhibit the translation of proteins with high requirement on the translation-initiation machinery (i.e., complex 5′-untranslated region UTR) relative to simple 5′UTR was determined by a cellular reporter assay. Simplified analogues of silvestrol such as compounds 74 and 76 were shown to have similar cytotoxic potency and better ADME characteristics relative to those of silvestrol.