1403380-46-0Relevant academic research and scientific papers
Total synthesis of leopolic acid A, a natural 2,3-pyrrolidinedione with antimicrobial activity
Dhavan, Atul A.,Kaduskar, Rahul D.,Musso, Loana,Scaglioni, Leonardo,Martino, Piera Anna,Dallavalle, Sabrina
, p. 1624 - 1628 (2016)
The first total synthesis of leopolic acid A, a fungal metabolite with a rare 2,3-pyrrolidinedione nucleus linked to an ureido dipeptide, was designed and carried out. Crucial steps for the strategy include a Dieckmann cyclization to obtain the 2,3-pyrrolidinedione ring and a Wittig olefination to install the polymethylene chain. An oxazolidinone-containing leopolic acid A analogue was also synthesized. The antibacterial activity showed by both compounds suggests that they could be considered as promising candidates for future developments.
