1403381-95-2

Upstream product

• 358-23-6 trifluoromethylsulfonic anhydride 
• 1666-04-2 2-hydroxy-3,6-dimethylbenzaldehyde 
• 37595-74-7 N,N-phenylbistrifluoromethane-sulfonimide 

Downstream Products

• 34341-29-2 2,3,6-trimethylbenzaldehyde 
• 1403380-98-2 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3,6-dimethylphenyl]acetic acid 
• 1403381-99-6 methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3,6-dimethylphenyl]acetate 
• 1403381-98-5 methyl 2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3,6-dimethylphenyl]-2-hydroxyacetate 
• 1403381-97-4 2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3,6-dimethylphenyl]-2-hydroxyacetonitrile 
• 1403381-96-3 2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3,6-dimethyl benzaldehyde 

Relevant academic research and scientific papers

One-step, stereoselective synthesis of octahydrochromanes via the Prins reaction and their cannabinoid activities

Novel, functionalized octahydrochromane derivatives were synthesized in a single step via the Prins reaction. Enantiomerically pure (+)-isopulegol was reacted with benzaldehyde to stereoselectively yield the corresponding octahydro-2H-chromen-4-ol derivative containing five stereocenters. A total of 10 compounds were synthesized by altering the enantiomer of isopulegol and the substituted benzaldehyde, and the resulting enantiopure octahydrochromanes were screened in vitro against the cannabinoid receptor isoforms CB1 and CB2. Compounds containing an olefin at the C4 position [(+)-3c, (?)-3c, (?)-7c, (?)-9c and (?)-11c] of the octahydrochromane scaffold were found to exhibit reasonable displacement of [3H] CP55,940 from the CB receptors, whereas the corresponding hydroxy analogs [(+)-3a, (+)-3b, (?)-3a, (?)-3b and (+)-5a] had very little or no effect.

Inhibitors of viral replication, their process of preparation and their therapeutical uses

The present invention relates to compounds, their use in the treatment or the prevention of viral disorders, including HIV.

A convenient synthesis of tri- and tetramethylbenzaldehydes from readily available phenols

This letter describes a convenient synthesis of the six isomeric tri- and tetramethylbenzaldehydes, which are not readily available from major chemical suppliers. Formylation of readily available phenols via electrophilic aromatic substitution provides compounds containing the correct aromatic substitution pattern. ?Suzuki cross-coupling of the corresponding trifluoromethanesulfonates with methylboronic acid then provides the benzaldehydes as single isomers. Georg Thieme Verlag Stuttgart. New York.

INHIBITORS OF VIRAL REPLICATION, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES

The present invention relates to compounds, their use in the treatment or the prevention of viral disorders, including HIV.