1403457-44-2

Basic information

• Product Name: 4-bromo-2-(tert-butyl)-phenyl acetate
• Synonyms: 4-bromo-2-(tert-butyl)-phenyl acetate
• CAS NO: 1403457-44-2
• Molecular Weight: 271.154
• Mol File: 1403457-44-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-bromo-2-(tert-butyl)-phenyl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromo-2-(tert-butyl)-phenyl acetate(1403457-44-2)
• EPA Substance Registry System: 4-bromo-2-(tert-butyl)-phenyl acetate(1403457-44-2)

Safety Data

• Hazardous Substances Data: 1403457-44-2(Hazardous Substances Data)

Upstream product

• 88-18-6 2-tert-Butylphenol 
• 108-24-7 acetic anhydride 
• 108-95-2 phenol 
• 10323-39-4 4-bromo-2-tert-butylphenol 

Relevant articles and documents

Bromination of phenols in bromoperoxidase-catalyzed oxidations

Phenol and ortho-substituted derivatives furnish products of selective para-bromination, if treated with sodium bromide, hydrogen peroxide, and the vanadate(V)-dependent bromoperoxidase I from the brown alga Ascophyllum nodosum. Relative rates of bromination in morpholine-4-ethane sulfonic acid (MES)-buffered aqueous tert-butanol (pH 6.2) increase by a factor 32, as the ortho-substituent in a phenol changes from F via Cl, OCH3, C(CH 3)3, and H to CH3. The polar effect in phenol bromination by the enzymatic method, according to a Hammett-correlation (ρ=-3), compares to reactivity of molecular bromine under identical conditions (ρ=-2). Hypobromous acid is not able to electrophilically substitute bromine for hydrogen at pH 6.2 in aqueous tert-butanol. The tribromide anion behaves in MES-buffered aqueous tert-butanol as electrophile (ρ～-3), showing a similar polar effect in phenol bromination as molecular bromine.